Autocrine Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) Pathway Activity Controls Intestinal Stem Cell Proliferation in the Adult Drosophila Midgut

Bond, David; Foley, Edan

doi:10.1074/jbc.m112.378018

Cited by 41 publications

(38 citation statements)

References 64 publications

(57 reference statements)

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“…We previously established that expression of pvrCA in posterior midgut progenitor cells accelerates ISC proliferation and increases the number of Dl-positive ISCs (15). esg[ts]-mediated induction of pvrCA greatly disrupted the pattern of GFP expression in adult midguts.…”

Section: Hyperproliferation Of Iscs Leads To Intestinal Distension Andmentioning

confidence: 99%

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A Deregulated Intestinal Cell Cycle Program Disrupts Tissue Homeostasis without Affecting Longevity in Drosophila

Petkau

Parsons

Duggal

et al. 2014

Journal of Biological Chemistry

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Background:We know comparatively little about the impact of deregulated intestinal proliferation on an otherwise normal animal. Results: Modified progression through the cell cycle disrupted homeostasis without affecting longevity. Conclusion: Disrupted intestinal homeostasis alone does not shorten the life span of an adult fly. Significance: These questions are of considerable importance, given the relationship between proliferation, dysplasia, aging, and death.

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Section: Hyperproliferation Of Iscs Leads To Intestinal Distension Andmentioning

confidence: 99%

“…Inputs from JAK/STAT, insulin, EGF, Wingless, PDGF, and VEGF pathways inform the rate of ISC division (10,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). In the absence of extrinsic challenges, these signals culminate in a division every 1-2 weeks (9,11).…”

mentioning

confidence: 99%

A Deregulated Intestinal Cell Cycle Program Disrupts Tissue Homeostasis without Affecting Longevity in Drosophila

Petkau

Parsons

Duggal

et al. 2014

Journal of Biological Chemistry

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“…• Notch (Bardin et al 2010 ;Ohlstein and Spradling 2007 ;Perdigoto et al 2011 ) • Insulin (Amcheslavsky et al 2009 ;Biteau et al 2010 ;Choi et al 2011 ;Kapuria et al 2012 ) • Epidermal growth factor (EGF) Buchon et al 2010 ;Jiang et al 2011 ;Xu et al 2011 ) • PDGF/VEGF receptor (Pvr) (Bond and Foley 2012 ;Choi et al 2008 ) • Target of rapamycin (TOR) (Amcheslavsky et al 2011 ;Kapuria et al 2012 ) • Janus kinase -signal transducer and activator of transcription (JAK-STAT) (Beebe et al 2010 ;Lin et al 2010 ;Liu et al 2010 ) • Hippo (Karpowicz et al 2010 ;Ren et al 2010 ;Shaw et al 2010 ;Staley and Irvine 2010 ) • Wnt/wingless and adenomatous polyposis coli (APC) (Cordero et al 2012 ;Lee et al 2009 ;Lin et al 2008 ) In addition, cell proliferation is rapidly induced in the intestine in response to stress and infection, in order to replace damaged differentiated cells and maintain the integrity of the epithelium. This proliferative response directly involves the activation of ISCs themselves, as no transit-amplifying cell population exists in the midgut, and relies on the induction of many conserved signaling pathways, such as:…”

Section: Posterior and Anterior Midgutmentioning

confidence: 99%

Aging of Intestinal Stem Cells in Drosophila Melanogaster

Biteau

2015

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

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Drosophila m . has a long history of major contributions to basic biology and biomedical research. Not surprisingly, the recent identifi cation of several multipotent stem cell populations in the Drosophila fl y digestive tract has generated an immense enthusiasm in the research community. This experimental model provides a unique opportunity to study adult somatic stem cells, using the power of fl y genetics. Over the past few years, research in this fi eld has focused on the characterization of the signaling pathways and mechanisms that control stem cell function and tissue repair in the intestine. Importantly, the rapid aging and short lifespan of Drosophila make this model ideal to investigate the impact of aging on stem cell populations and test the contribution of somatic stem cells to normal healthspan and lifespan. This chapter presents recent fi ndings that elucidate the mechanisms causing age-related loss of tissue homeostasis in the fl y intestine, as well as strategies of stem cell-specifi c genetic manipulation that signifi cantly impact physiology in aging animals and can extend lifespan. IntroductionWith the identifi cation of stem cell populations in the developing larval brain and the gonads, studies in Drosophila have been pivotal to the discovery of fundamental processes that regulate stem cell biology in many other stem/progenitor compartments. For example, many conserved mechanisms that control asymmetric cell division and cell specifi cation were fi rst identifi ed in larval neuroblasts (Knoblich 2010 ), while studies of the germline stem cells in the fl y testis and ovary

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“…Preventing JAK/Stat signalling through knock down of Drosophila Hop/JAK, the cytokine receptor Domeless or the transcription factor Stat leads to an overrepresentation of stem/progenitor cells in the adult midgut (Beebe et al, 2010). Autocrine activation of PVF2/PVR signalling also regulates homeostatic ISC proliferation and differentiation (Bond and Foley, 2012). Additionally, recent reports show that the Snail homolog Escargot (Esg), which is expressed in stem/progenitor cells (Micchelli and Perrimon, 2006), is essential for the maintenance of ISCs in the adult midgut.…”

Section: Basal Homeostatic Self-renewal Of the Adult Drosophila Midgutmentioning

confidence: 99%

Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut

Nászai

Carroll

Cordero

2015

Insect Biochemistry and Molecular Biology

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Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches (Nystul and Spradling, 2006).The intestinal epithelium has a remarkable regenerative capacity, which has made it a prime paradigm for the study of stem cell-driven tissue self-renewal. The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted our understanding of the role of stem cells in intestinal homeostasis. Here we will review the current knowledge of the main mechanisms involved in the regulation of tissue homeostasis in the adult Drosophila midgut, with a focus on the role of stem cells in this process. We will also discuss processes involving acute or chronic disruption of normal intestinal homeostasis such as damage-induced regeneration and ageing.3

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Autocrine Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) Pathway Activity Controls Intestinal Stem Cell Proliferation in the Adult Drosophila Midgut

Cited by 41 publications

References 64 publications

A Deregulated Intestinal Cell Cycle Program Disrupts Tissue Homeostasis without Affecting Longevity in Drosophila

A Deregulated Intestinal Cell Cycle Program Disrupts Tissue Homeostasis without Affecting Longevity in Drosophila

Aging of Intestinal Stem Cells in Drosophila Melanogaster

Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut

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