Autoerythrocyte sensitization(Gardner–Diamond) syndrome

Abstract

We describe the clinical presentation and course of a patient with autoerythrocyte sensitization (Gardner-Diamond) syndrome, and review the literature for similar cases. A 37-yr-old female presented with recurrent episodes of painful ecchymotic bruising over the anterior aspect of both thighs. These episodes were precipitated by emotional stress. The diagnosis was confirmed by induction of similar lesions by intradermal injection of the patient's own washed red blood cells and hemoglobin. The lesions did not recur for 6 months after the cause of her emotional stress was relieved. Autoerythrocyte sensitization (Gardner-Diamond) syndrome should be considered in the differential diagnosis of purpura, especially in patients with psychiatric problems.

Autoerythrocyte sensitization syndrome presenting with general neurodermatitis

“…However, the lesions have recurred for as long as 30-40 years. In some cases, the syndrome may remit for months or years and return at a time of severe emotional stress [7]. …”

Perplexing purpura in two females: Rare case of autoerythrocyte sensitization syndrome

“…[5] A number of hematological and immunological abnormalities have been described including thrombocytosis, defective thrombocyte aggregation, increased activated partial thromboplastin time,[1] morphological abnormalities in RBCs, functional platelet defect, idiopathic thrombocytopenic purpura, and abnormally increased tissue plasminogen activator (tPA) dependent cutaneous fibrinolytic activity. [6] Psychological factors play an important role in the pathogenesis. Agle and Ratnoff noted marked emotional liability in the patients coinciding with psychic stress.…”

Autosensibilisation aux érythrocytes (syndrome de Gardner-Diamond) associée à une vascularite cutanée

“…Ce syndrome n'est pas classé parmi les maladies immuno-inflammatoires car les biopsies cutanées ne montrent pas de signes inflammatoires. Les signes histologiques consistent en un oedème du derme, une extravasation des érythrocytes et des infiltrats aigus inflammatoires périvasculaires [8,10].…”

“…Ratnoff a décrit les lésions du syndrome de Gardner-Diamond comme des ecchymoses inflammatoires [2]. De plus, la corticothérapie est utile dans certains cas de syndrome de Gardner-Diamond [10].…”