Autofluorescence endoscopy in surveillance of Barrett’s esophagus: a multicenter randomized trial on diagnostic efficacy

Abstract

In this referral Barrett's esophagus population with a higher prevalence of neoplastic lesions, the AFE-guided approach improved the diagnostic yield for neoplasia in comparison with the conventional approach using four-quadrant biopsies. However, AFE alone was not suitable for replacing the standard four-quadrant biopsy protocol.

Multiple-Band Imaging Provides Better Value Than White-light Endoscopy in Detection of Dysplasia in Patients With Barrett's Esophagus

“…During the past decade, several technical improvements have lead endoscopy into a new era of advanced imaging modalities (Suppl. Table 1) [7][8][9][10][11][12][13] . These novel methods aid the investigator in delineating the metaplastic epithelium and in taking targeted biopsies from subtle focal lesions, such as mucosal and microvascular irregularities, and polyps 14 .…”

“…After reviewing the literature, we found six studies out of 225 that were relevant to the question. They were all prospective, randomized controlled trials 7,9,[17][18][19][20] . At that time, no studies had compared multiple-band imaging (MBI) with targeted biopsies and the standard procedure.…”

Benefit of baseline cytometry for surveillance of patients with Barrett’s esophagus

“…Samples were processed according to a standardized protocol, as described previously in detail [11]. Briefly, DICM was performed with a continuous collision detection (CCD) three-chip color video camera (Sony) and an AutoCyte QUIC DNA workstation on Feulgen-restained cytology smears.…”

An Inter-Observer Agreement Study of Autofluorescence Endoscopy in Barrett’s Esophagus Among Expert and Non-Expert Endoscopists

“…The abnormal areas are seen in ''magenta'' or ''purple'' color compared to the normal tissue in ''green'' color depicting the absorption spectrum of hemoglobin. However, the specificity of AFI was low with significant false positive rates in all the studies [4][5][6][7]. The AFI is thus predominantly used as ''red flag'' technique to highlight suspicious areas which can then be closely observed with HRE or narrow band imaging (NBI) with magnification to look at the vascular and pit patterns [8,9].…”