Autofluorescence Imaging of Cystoid Macular Edema in Diabetic Retinopathy

Pece, Alfredo; Isola, Vincenzo; Holz, Frank G.; Milani, Paolo; Brancato, Rosario

doi:10.1159/000260229

Cited by 49 publications

(67 citation statements)

References 18 publications

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“…11,12,14,31 The areas of autofluorescent cystoid spaces at the fovea were reported to be related to visual impairment, retinal thickness, and photoreceptor damage. 14 Vujosevic et al 12 reported that eyes with the multiple-spot type of autofluorescent cystoid spaces had poorer VA than those with the single-spot type.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Yoshitake

Murakami

Uji

et al. 2015

Eye

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Purpose To quantify the signal intensity of fundus autofluorescence (FAF) and evaluate its association with visual function and optical coherence tomography (OCT) findings in diabetic macular oedema (DMO). Methods We reviewed 103 eyes of 78 patients with DMO and 30 eyes of 22 patients without DMO. FAF images were acquired using Heidelberg Retina Angiograph 2, and the signal levels of FAF in the individual subfields of the Early Treatment Diabetic Retinopathy Study grid were measured. We evaluated the association between quantified FAF and the logMAR VA and OCT findings. Results One hundred and three eyes with DMO had lower FAF signal intensity levels in the parafoveal subfields compared with 30 eyes without DMO. The autofluorescence intensity in the parafoveal subfields was associated negatively with logMAR VA and the retinal thickness in the corresponding subfields. The autofluorescence levels in the parafoveal subfield, except the nasal subfield, were lower in eyes with autofluorescent cystoid spaces in the corresponding subfield than in those without autofluorescent cystoid spaces. The autofluorescence level in the central subfield was related to foveal cystoid spaces but not logMAR VA or retinal thickness in the corresponding area. Conclusions Quantified FAF in the parafovea has diagnostic significance and is clinically relevant in DMO.

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Section: Discussionmentioning

confidence: 99%

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Yoshitake

Murakami

Uji

et al. 2015

Eye

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“…Sekiryu et al 19 reported that autofluorescence generated by the RPE cells travels through the sensory retina, and the intensity of the FAF changes according to the status of the overlying retina. Pece et al 20 reported that increased FAF during CME in patients with diabetes was not abnormal FAF, but instead, was the normal fluorescence of the RPE as observed through a defect in the xanthophyll pigment. However, they also reported that the visual acuity of patients with diabetic macular edema with increased FAF was worse than that of patients without increased FAF.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Fundus Autofluorescence With Foveal Microstructures and Vision in Branch Retinal Vein Occlusion

Park

Chung

Kim

2014

Retina

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The shorter length of photoreceptor inner and outer segment junction and external limiting membrane defect and less FAF pre-IVB showed a significant association with better visual acuity post-IVB. These associations could help to predict potential restoration of photoreceptor integrity and visual recovery in patients with branch retinal vein occlusion, in whom photoreceptor integrity before treatment could not be adequately evaluated, even with spectral domain optical coherence tomography.

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“…13 Fundus autofluorescence (FAF) imaging using a confocal scanning laser ophthalmoscope (cSLO) allows for topographic assessment of macular pathology with high resolution. Pece et al 14 found that conventional FAF imaging with a wavelength of 488 nm provides a sensitive, rapid and non-invasive way of assessing DMO, correlating well with FA and findings on OCT imaging. Vujosevic and colleagues 15 also described good correlation between FAF, OCT, FA and central field microperimetry.…”

Section: Introductionmentioning

confidence: 88%

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

Waldstein

Hickey

Mahmud

et al. 2012

Eye

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Purpose To evaluate the application of 488 and 514 nm fundus autofluorescence (FAF) and macular pigment optical density (MPOD) imaging in diabetic macular oedema (DMO) and to demonstrate the typical imaging features. Patients and Methods A hundred and twentyfive eyes of 71 consecutive patients with diabetic retinopathy who underwent examination at a specialist university clinic employing a modified Heidelberg Retina Angiograph, using two different light sources of 488 and 514 nm wavelength, were retrospectively reviewed. MPOD images were calculated using modified Heidelberg Eye Explorer software. All images were evaluated by two independent masked graders. Features from FAF and MPOD images were correlated with optical coherence tomography (OCT) imaging findings and inter-grader variability, sensitivity and specificity were calculated using OCT as reference. Results Sixty-seven eyes had DMO on OCT. The inter-grader variability was 0.84 for 488 nm FAF, 0.63 for 514 nm FAF and 0.79 for MPOD imaging. Sensitivity and specificity for detection of DMO were 80.6 and 89.7% for 488 nm FAF; 55.2 and 94.8% for 514 nm FAF; and 80.6 and 91.4% for MPOD imaging. In 488 nm FAF and MPOD imaging, DMO was better visualised in comparison with 514 nm FAF imaging, Po0.01. MPOD revealed displacement of macular pigment by intraretinal cysts. Conclusion MPOD imaging, and particularly its combination with 488 nm and 514 nm FAF, provides a valuable addition to OCT in the evaluation of DMO and is clinically useful in rapid en-face assessment of the central macula.

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Autofluorescence Imaging of Cystoid Macular Edema in Diabetic Retinopathy

Cited by 49 publications

References 18 publications

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Correlation of Fundus Autofluorescence With Foveal Microstructures and Vision in Branch Retinal Vein Occlusion

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

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