Autofluorescence (safe) bronchoscopy and p21/ki-67 immunostaining related to carcinogenesis

Horváth, Teodor; Hirano, Takashi; Horváthová, Mária; Vomela, Jindřich; Vyzula, Rostislav; Číhalová, Marta; Dorociak, F.; Ebihara, Yoshiro; Furukawa, Kinya; Habanec, B; Ikeda, Norihiko; Kakihana, Masatoshi; Klusáková, J; Okada, Shinya; Rejthar, A; Stratil, Dalibor; Shaffi-Sahely, A; Smajer, B; Špelda, Stanislav; Tsuboi, Masahiro; Vagunda, Václav; Wurst, F; Kato, Harubumi

doi:10.1016/s1572-1000(04)00005-5

Cited by 1 publication

(1 citation statement)

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“…The discovery of in situ endobronchial cancer and early detection of the local recurrence are greatly assisted by autofluorescence bronchoscopy, which can provide localization of the lesion in cases where the lesion may not be visible by the usual white light bronchoscopy. [60][61][62] Over 95% of PDTs in lung cancer are performed bronchoscopically for central-type lung cancer and usually for nonsmall cell lung cancer histology. Bronchoscopic PDT is performed in the usual two steps, that is, systemic presensitization followed by an interval of illumination using the bronchoscope's instrumental channel to accommodate the laser delivery fiber.…”

Section: Head and Neckmentioning

confidence: 99%

A Surgical View of Photodynamic Therapy in Oncology: A Review

Moghissi

Dixon

Gibbins

2015

Surg J

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Clinical photodynamic therapy (PDT) has existed for over 30 years, and its scientific basis has been known and investigated for well over 100 years. The scientific foundation of PDT is solid and its application to cancer treatment for many common neoplastic lesions has been the subject of a huge number of clinical trials and observational studies. Yet its acceptance by many clinicians has suffered from its absence from the undergraduate and/or postgraduate education curricula of surgeons, physicians, and oncologists. Surgeons in a variety of specialties many with years of experience who are familiar with PDT bear witness in many thousands of publications to its safety and efficacy as well as to the unique role that it can play in the treatment of cancer with its targeting precision, its lack of collateral damage to healthy structures surrounding the treated lesions, and its usage within minimal access therapy. PDT is closely related to the fluorescence phenomenon used in photodiagnosis. This review aspires both to inform and to present the clinical aspect of PDT as seen by a surgeon.

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Section: Head and Neckmentioning

confidence: 99%