Autogenous bone grafting

Hofbauer, Mark H.; Delmonte, Rick; Scripps, Mark L.

doi:10.1016/s1067-2516(96)80056-1

Cited by 19 publications

(4 citation statements)

References 14 publications

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“…Bone regeneration following surgical removal of bone and injuries from sports, trauma, and disease is a challenging obstacle in clinical treatment because it can easily change course and impair the patient’s quality of life. To augment bone regeneration, autografts and allografts are widely used to treat bone defects [1,2], and they are often applied clinically via the Masquelet technique [3] and the Reamer-Irrigator-Aspirator system [4], either independently or in combination. Although using bone grafts during these procedures possess desirable attributes, such as molecular cues, osteogenic cells, and niche for bone regrowth, retrieving these bone grafts still requires invasive and possibly fatal surgeries [5].…”

Section: Introductionmentioning

confidence: 99%

Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects

et al. 2018

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Cryogels have recently gained interest in the field of tissue engineering as they inherently possess an interconnected macroporous structure. Considered to be suitable for scaffold cryogel fabrication, methacrylated gelatin (GelMA) is a modified form of gelatin valued for its ability to retain cell adhesion site. Bioglass nanoparticles have also attracted attention in the field due to their osteoinductive and osteoconductive behavior. Here, we prepare methacrylated gelatin cryogel with varying concentration of bioglass nanoparticles to study its potential for bone regeneration. We demonstrate that an increase in bioglass concentration in cryogel leads to improved mechanical property and augmented osteogenic differentiation of mesenchymal cells during in vitro testing. Furthermore, in vivo testing in mice cranial defect model shows that highest concentration of bioglass nanoparticles (2.5 w/w %) incorporated in GelMA cryogel induces the most bone formation compared to the other tested groups, as studied by micro-CT and histology. The in vitro and in vivo results highlight the potential of bioglass nanoparticles incorporated in GelMA cryogel for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects

et al. 2018

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“…A great deal of the foot and ankle surgical literature focuses on first MTPJ arthrodesis, particularly the need that sometimes arises for an interposition allogeneic or autogenous bone graft to fill large osseous deficits within the first MTPJ (20,21). This commonly occurs following infection, nonunion, or AVN.…”

Section: Figure 19mentioning

confidence: 99%

Reconstruction of the First Metatarsophalangeal Joint Following Post-cheilectomy Avascular Necrosis of the First Metatarsal Head: A Case Report

Brosky

Menke

Xenos³

2009

The Journal of Foot and Ankle Surgery

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“…Several bone substitutes have been described for bone regeneration, but only autografts present all the properties mentioned above . However, because of its limited availability and the post-operative complications associated with the harvesting of autografts, such as donor site pain and morbidity, , the development of new synthetic materials resembling the properties of bone has been promoted.…”

Section: Introductionmentioning

confidence: 99%

Novel Osteoinductive and Osteogenic Scaffolds of Monetite, Amorphous Calcium Phosphate, Hydroxyapatite, and Silica Gel: Influence of the Hydroxyapatite/Monetite Ratio on Their In Vivo Behavior and on Their Physical and Chemical Properties

Padilla

Benito-Garzón

Enciso

et al. 2020

ACS Biomater. Sci. Eng.

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In this work, a new family of multiphasic materials composed of the same amount of silica gel and variable amount of three calcium phosphates with very different solubilities, monetite > amorphous calcium phosphate > hydroxyapatite (HAp), was studied. Silicon was added to calcium phosphate to increase bioactivity and osteinductivity. The influence of the HAp/monetite ratio on the material resorption and bone regeneration was investigated in critical bone defects in sheep and was related to their chemical and physical properties. It was concluded that a minimum rate of HAp/monetite is necessary to achieve an appropriate compromise between material resorption and bone regeneration. Above this minimum rate, bone regeneration and material resorbtion did not change significantly. Physical properties such as particle size, specific surface area, porosity, and granulate cohesion played a more critical role on material resorption than the solubility of their components. A huge difference between in vitro solubility and in vivo resorption was observed. It was related to the fastest cellular-mediated resorption of monetite compared to the other components. Computerized axial tomography, histology, histomorphometric, and multiple fluorochrome labeling studies showed a very advanced bone regeneration of the defects when materials with the highest HAp/monetite rate were implanted. It was also demonstrated that all materials induce bone formation and vascularization.

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Autogenous bone grafting

Cited by 19 publications

References 14 publications

Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects

Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects

Reconstruction of the First Metatarsophalangeal Joint Following Post-cheilectomy Avascular Necrosis of the First Metatarsal Head: A Case Report

Novel Osteoinductive and Osteogenic Scaffolds of Monetite, Amorphous Calcium Phosphate, Hydroxyapatite, and Silica Gel: Influence of the Hydroxyapatite/Monetite Ratio on Their In Vivo Behavior and on Their Physical and Chemical Properties

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