Autoimmune antibody-associated encephalopathy and dementia syndromes

Fredericks, Carolyn A.; Geschwind, Michael D.

doi:10.1017/9781139924771.023

Cited by 1 publication

(2 citation statements)

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“…The second group patients were assigned to, was according to the patient's final diagnosis: based on the International Classification of Diseases 11th Revision for Mortality and Morbidity Statistics (ICD-11 MMS) published by the World Health Organization, diagnoses were grouped into 'diagnostic groups' . Medical files of patients considered to have a PNS by the consulting neurologist, were examined by the authors to ascertain compliance with the diagnostic criteria for PNS and subsequently assigned to the PNS group [7,10,11,18,19]. Diseases without a clear alignment to any subdivision of the ICD-11 MMS were assigned to their respective diagnostic groups based upon authors' consensus after consulting clinical and laboratory results.…”

Section: Patient Classificationmentioning

confidence: 99%

“…Often, PNS and corresponding Ab surface before a tumor is discovered [5][6][7][8][9]. Therefore, it is important to meticulously search for AN Ab since they might urge clinicians to initiate oncological screening [10,11]. Moreover, since some Ab are closely linked with a certain PNS, detection of AN Ab facilitates the diagnosis of that specific PNS.…”

Section: Introductionmentioning

confidence: 99%

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The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening

Godelaine

Bossuyt

Poesen

2019

Autoimmun Highlights

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Screening for paraneoplastic antibodies is often performed by means of indirect immunofluorescence on primate cerebellar slices. However, atypical immunofluorescence patterns, i.e. patterns that are not specifically related to paraneoplastic antibodies, are often reported. The clinical significance of these patterns is not clear. Therefore, the purpose of this study was to determine the significance and diagnostic value-in terms of a paraneoplastic neurological syndrome or other neurological disease being diagnosed in the patient-of such atypical immunofluorescence screening patterns on primate cerebellum. Methods: This study is a retrospective single center study including atypical indirect immunofluorescence screening patterns of patients with a negative or absent typing assay for intraneuronal and anti-amphiphysin paraneoplastic antibodies. Patients with a positive typing assay or without final diagnosis were excluded. Included patients were grouped according to (i) reported immunofluorescence pattern and (ii) established diagnosis, after which contingency table analyses were performed to investigate an interrelation between reported pattern and diagnostic group. Results: In 3.7% of cases, patients with an atypical pattern obtained a final diagnosis of a paraneoplastic neurological syndrome. The presence of atypical patterns was more prominent in patients with epilepsy or peripheral neuropathies (p Monte Carlo simulation = 0.026), without, however, adding any diagnostic information. Conclusions: An atypical indirect immunofluorescence pattern on primate cerebellum in the screening for paraneoplastic antibodies has only very minor relevance with respect to paraneoplastic neurological syndromes or any other neurological disease, recommending clinicians to interpret the results of positive screening assays for such antibodies with care.

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