Autoimmune autonomic neuropathies: time to look beyond autoimmune autonomic ganglionopathy

Muppidi, Srikanth

doi:10.1007/s10286-017-0496-5

Cited by 5 publications

(1 citation statement)

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“…AAG is primarily a post-ganglionic disorder thought to involve antibodies that target the nicotinic acetylcholine receptor (gAChR) [ 1 ]. In the idiopathic form, it is thought that the body spontaneously generates autoantibodies against gAChR [ 2 ]. When caused by a primary neoplasm, the immune system produces paraneoplastic antibodies that cross-react and bind to the body’s gAChR system [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Autonomic Ganglionopathy Presenting as Constipation

Ahmed¹,

Lohman²,

Suresh³

et al. 2022

Cureus

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Autoimmune autonomic ganglionopathy (AAG) is a rare post-ganglionic disorder that causes a range of symptoms, often including gastrointestinal disorders. Patients may be seropositive or seronegative for antibodies against the nicotinic acetylcholine receptor. Here, we describe the case of a 56-year-old woman with a previous diagnosis of sensorimotor peripheral neuropathy who presented with severe constipation that was not responsive to laxative therapy. The evaluation showed diffuse colonic hypomotility, rectal hypersensitivity, and type IV pelvic floor dysfunction. The patient was diagnosed 10 months after the presentation as having seronegative AAG, and she responded well to treatment with intravenous methylprednisolone and apheresis.

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Section: Introductionmentioning

confidence: 99%