Autoimmune blistering diseases: Histologic meaning

Radoš, Jaka

doi:10.1016/j.clindermatol.2011.01.007

Cited by 21 publications

(78 citation statements)

References 37 publications

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“…One of these patients had nasal involvement alone which is a rare observation according to Weedon 11 , while the rest had oral lesions. Pemphigus foliaceous cases showed similar lesions without oral lesions which correlates with Rados J study 5 . IJBAR (2013) 04 (09) www.ssjournals.com All cases of Bullous pemphigoid showed tense blisters, and all 3 cases of Dermatitis herpetiformis had vesicles with crusted lesions and none had any symptoms of gluten-sensitive enteropathy.…”

Section: Clinical Presentationsupporting

confidence: 81%

“…Subepidermal bulla was seen in 11 cases which comprises of 8 cases of BP and one case each DH, EBA and Bullous LE. Only micropapillary abscess without bulla was found in 2 cases of DH and 1 case of LAD, which is a more important diagnostic finding as reported by Rados J study 5 .…”

Section: Histopathologysupporting

confidence: 62%

“…Pemphigus vulgaris presents with flaccid blisters, most rupture leaving behind denuded areas 10. A study by Rados J reported 100% cases of PV presenting with mucosal involvement 5 . In our study all except one, who was on remission had mucosal lesions (93%).…”

Section: Clinical Presentationmentioning

confidence: 99%

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Direct immunofluorescence study in autoimmune bullous disorders of skin

Kambi¹,

Santosh²,

Sugnua³

et al. 2013

Int J of Biomed & Adv Res

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Background and objectives: This study was taken up to know the utility of application of Direct Immunofluorescence on skin biopsies with particular reference to Autoimmune Bullous disorders.

The objectives of the present study was to detect specific patterns of DIF in different Autoimmune bullous disorders, to supplement clinical and histopathological features, and hence for confirmatory diagnosis of these disorders.

Methods: DIF using fluorescent labelled antibodies – IgG, IgM, IgA and C3 - was carried out in 60 clinically suspected cases of Autoimmune bullous disorders referred to Department of Pathology, KIMS Hospital and Research Center, Bangalore, over a period of 18 months from January 2011 to July 2012.

Results: Out of 60 cases analysed, 39 cases were given a final diagnosis as Autoimmune bullous disorder based on clinical, histopathological and DIF findings. DIF positivity was observed in 34 cases. DIF findings correlated with clinical and histopathological findings in 37 cases (94.8%).

Interpretation and Conclusion: In this study we found out that DIF serves as a simple, highly sensitive, cost-effective and hence gold standard test for Autoimmune bullous disorders. The technique is essential to supplement clinical findings and histopathology in the diagnosis of these Immunobullous disorders.

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Section: Clinical Presentationsupporting

confidence: 81%

Section: Histopathologysupporting

confidence: 62%

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Direct immunofluorescence study in autoimmune bullous disorders of skin

Kambi¹,

Santosh²,

Sugnua³

et al. 2013

Int J of Biomed & Adv Res

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Background and objectives: This study was taken up to know the utility of application of Direct Immunofluorescence on skin biopsies with particular reference to Autoimmune Bullous disorders.

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“…Characteristically, the clefts and pustules localize in the subcorneal region in SPD type IGAP, whereas they are present in the entire or mid epidermis in IEN type IGAP (3,16). In the upper dermis, a superficial perivascular and interstitial infiltrates of lymphocytes, neutrophils and sometimes eosinophils are present (19) Desmocollin 1 (Dsc1) has recently been identified as the target antigen of the SPD type (15). In the IEN type, no reactivity of autoantibodies with Dsc 1, 2, and 3 has been found, whereas desmoglein 1 and 3 were suggested as putative target antigens of IEN type in single case reports (20,21).…”

Section: Discussionmentioning

confidence: 98%

“…In both variants, the blisters contain acantholytic keratinocytes and a variable number of neutrophils (19). Acantholysis in IgA pemphigus is much milder than in classic pemphigus.…”

Section: Discussionmentioning

confidence: 99%

IgA Pemphigus in a Child – a Case Report

Lekić

Gajić-Veljić

Popadić

et al. 2017

Serbian Journal of Dermatology and Venereology

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IgA pemphigus (IGAP) is a rare autoimmune bullous disease characterized by IgA deposits on keratinocyte cell surfaces. The IGAP is classified into: 1) subcorneal pustular dermatosis (SPD) type, and 2) intraepidermal neutrophilic (IEN) IgA dermatosis type. So far, only 9 children with IGAP have been described in the literature, of whom only 3 with SPD type. We report a 3-year-old boy with SPD type of IGAP. Clinically, he presented with pruritic vesicles, pustules and erosions on the face, trunk, groin area, and extremities. Histopathology showed subcorneal pustules containing a few acantholytic cells. Direct immunofluorescence (DIF) test of Tzanck smear showed intercellular IgA deposits on the surface of the groups of epidermal cells. Oral dapsone and prednisone induced remission after two weeks; the treatment was discontinued 11 months later, and complete remission was achieved during 19 months without any treatment. Direct immunofluorescence of Tzanck smear is a simple, sensitive, rapid and non-aggressive test, very suitable for the diagnosis of IGAP in children.

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Dermatitis Herpetiformis

Lakoš Jukić,

Marinovic

2023

European Handbook of Dermatological Treatments

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Autoimmune blistering diseases: Histologic meaning

Cited by 21 publications

References 37 publications

Direct immunofluorescence study in autoimmune bullous disorders of skin

Direct immunofluorescence study in autoimmune bullous disorders of skin

IgA Pemphigus in a Child – a Case Report

Dermatitis Herpetiformis

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