Autoimmune disease comorbidities in patients with atopic dermatitis: a nationwide case–control study in Taiwan

Wu, Li-Chiu; Hwang, Chian Yaw; Chung, Pei I.; Hua, Tuan-Chun; Chen, Yen Da; Chu, Szu Yin; Lee, Din Dar; Chang, Yun Ting; Wang, Wen Jen; Liu, Han Nan; Chen, Chih Chiang

doi:10.1111/pai.12274

Cited by 50 publications

(72 citation statements)

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“…As T and B helper cells are involved in the pathogenesis of both atopy and autoimmune disease, a positive association is speculated [46]. Many common immune pathways underlying autoimmune disease and atopy, featuring Th2, Th17, Treg, and Toll-like receptors (TLRs) have been the subject of several recent reports [17–20, 47]. …”

Section: Discussionmentioning

confidence: 99%

“…Some indications for the plausibility of underlying similarities are the rise in prevalence of both disease groups in the 20th century [15]. Previous researches showed epidemiological correlations and a substantial pathophysiological relationship between atopy and SLE [2, 16, 17]. Furthermore, many recent discoveries have challenged that there is no connection between atopic diseases and autoimmune disorders and even suggested that autoimmune and atopic diseases may be risk factors for each other, contributing to the high prevalence of both diseases [2, 13, 16, 18,19].…”

Section: Introductionmentioning

confidence: 99%

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Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Guo

Zhou

et al. 2017

PLoS ONE

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The influence of co-existing atopy on the prognosis of juvenile systemic lupus erythematosus (JSLE) was assessed in this study. Patients diagnosed with JSLE between October 2005 and April 2016 were enrolled in a prospective study and followed up for 2 years. Management of patients was evaluated using the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score and laboratory variables. Eighty JSLE patients were enrolled at diagnosis and divided into those with (n = 35) and without (n = 45) atopy. When compared with the non-atopic group, atopic patients showed higher SLEDAI-2K score at disease onset (16.09 vs. 11.18), higher erythrocyte sedimentation rate (52.89 vs. 38.27 mm/h), higher percentage of total B-cells (25.85 vs. 19.51%), lower percentage (7.26 vs. 9.03%) and cytotoxicity (9.92 vs. 11.32%) of natural killer cells, and lower complement C3 (0.51 vs. 0.69 g/L) (all p<0.05). At 1, 3, 6, 12, 18, and 24 months, JSLE patients with atopy reached higher SLEDAI-2K score and lower ΔSLEDAI-2K improvement rate (at 1 month, 8.34 vs. 4.71 and 43.63 vs. 57.95%, respectively; at 3 months, 8.57 vs. 2.62 and 48.39 vs. 75.10%, respectively; at 6 months, 6.91 vs. 2.38 and 53.59 vs. 77.26%, respectively; at 12 months, 4.71 vs. 1.80 and 69.54 vs. 84.10%, respectively; at 18 months, 4.66 vs. 2.02 and 68.14 vs. 82.93%, respectively; at 24 months, 8.57 vs. 2.62 and 70.00 vs. 81.88%, respectively; all p<0.05). During the 24 months of follow-up, the total number of disease flares was higher in JSLE patients with co-existing atopy (3.77 vs. 1.51, p<0.05), and the atopic group needed much more time to reach the stable condition of the disease (6.88 vs. 4.65 months, p<0.05). JSLE patients combined with co-existing atopy had more severe disease at diagnosis and poorer outcomes than JSLE patients without atopy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Guo

Zhou

et al. 2017

PLoS ONE

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“…Interestingly, in one study, maternal rheumatoid arthritis/ankylosing spondylitis was shown to be associated with both asthma and hay fever in her children, although they did not report any association with AD . No positive or negative associations were found with endocrine autoimmune disease despite an inconsistently reported inverse association between type 1 diabetes and AD …”

Section: Discussionmentioning

confidence: 95%

“…3,5 Atopic dermatitis has been associated with a wide variety of autoimmune conditions including dermatologic diseases including vitiligo, 6,7 alopecia areata [6][7][8][9] and chronic urticaria, 6 but also gastrointestinal autoimmune diseases such as ulcerative colitis, 6,[10][11][12][13] Crohn's disease, 6,10,[12][13][14] and coeliac disease 6,15,16 and rheumatologic autoimmune diseases such as systemic lupus erythematosus. 6,17 Mixed or non-significant associations have been reported with diabetes mellitus type 1, 10,17,18 rheumatoid arthritis 10,[19][20][21] and ankylosing spondylitis. 19,20 The observed associations may be explained in part by surveillance bias in registerbased studies, but overlap in genetic risk loci has indeed been identified suggesting that AD and autoimmune diseases may have shared origin.…”

Section: Introductionmentioning

confidence: 99%

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study

Hamann

Egeberg

Silverberg

et al. 2019

Acad Dermatol Venereol

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Background Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children. Materials and methods All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Maternal and paternal autoimmune diseases were assessed using registry‐based data. Conditional logistic regression was performed on the relationships between parental autoimmune diseases and AD in their children. Results A total of 8589 children with AD were matched with controls. One or more autoimmune disease was identified in 5.89% (506/8589) of mothers to AD children and 3.67% (315/8589) of fathers to AD children compared to 4.85% (4163/85 890) and 3.28% (2816/85 890) in parents of control children. Maternal autoimmune disease but not paternal autoimmune disease was associated with AD in the offspring (odds ratio [OR] 1.20 [95% confidence interval (CI) 1.20–1.32] and OR 1.08 [0.96–1.22], respectively), Two or more maternal autoimmune diseases, maternal dermatologic autoimmune disease and maternal digestive autoimmune disease were all also associated with AD development in her children (1.96 [95% CI 1.36–2.84], OR 1.60 [95% CI 1.24–2.07] and OR 1.24 [95% CI 1.06–1.45], respectively). Conclusions The risk of AD is influenced by many factors including atopy status and filaggrin gene mutations. In this matched case–control study, maternal autoimmune disease was associated with AD diagnosis in the offspring. Maternal dermatologic and digestive autoimmune diseases were most closely associated with subsequent AD diagnosis in the offspring.

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“…In this study, Lung‐chi and Chian‐Yaw et al . adopted the National Health Insurance Research Database (NHIRD) from the National Health Insurance (NHI) program, a public healthcare system enrolled more than 99% population in Taiwan, to examine the association of AD and several autoimmune diseases.…”

Section: Autoimmune Disease Comorbidities In Patients With Atopic Dermentioning

confidence: 99%

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Pediatric Allergy Immunology

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Autoimmune disease comorbidities in patients with atopic dermatitis: a nationwide case–control study in Taiwan

Abstract: Our study confirmed the association between AD and LE. Early survey for LE in juvenile patients with AD is recommended.

Cited by 50 publications

References 53 publications

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study

The Editor recommends this issue's articles to the reader

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