Autoimmune diseases

Harsini, Sara; Rezaei, Nima

doi:10.1016/b978-0-12-818006-8.00001-3

Cited by 6 publications

(3 citation statements)

References 1,097 publications

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“…The role of autoantibodies in fibrosis, particularly in radiation-induced skin conditions, adds another layer of complexity to the immune dysregulation observed in fibrosis. Autoantibodies, typically associated with autoimmune disorders, may contribute to tissue damage either directly or by forming immune complexes that deposit in tissues, triggering further inflammation ( 119 ). This inflammation can lead to fibroblast activation and the perpetuation of the fibrotic response.…”

Section: Molecular Mechanisms Of Fibrosismentioning

confidence: 99%

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Wang,

Chen,

Bao

et al. 2024

Front. Immunol.

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This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed the cellular and molecular responses of the skin to radiation, highlighting the role of myofibroblasts and the significant impact of Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The review delves into the epigenetic regulation of fibrotic gene expression, the contribution of extracellular matrix proteins to the fibrotic microenvironment, and the regulation of the immune system in the context of fibrosis. Additionally, it discusses the potential of biomaterials and artificial intelligence in medical research to advance the understanding and treatment of radiation-induced skin fibrosis, suggesting future directions involving bioinformatics and personalized therapeutic strategies to enhance patient quality of life.

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Section: Molecular Mechanisms Of Fibrosismentioning

confidence: 99%

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Wang,

Chen,

Bao

et al. 2024

Front. Immunol.

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“…Rheumatoid arthritis (RA) is a persistent autoimmune disease characterized by chronic inflammation and polyarthritis of unknown origin, impacting multiple systems in the body [ 1 ]. According to field studies, the prevalence of RA is estimated to be around 70% of the population [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients

Elfituri

2024

Reumatologia

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ObjectivesThis study aimed to investigate the effect of vitamin D supplementation therapy on disease activity and fatigue in rheumatoid arthritis (RA) patients.Material and methodsA prospective randomized clinical trial was conducted at rheumatology clinics in Tripoli Central Hospital, Libya. The eligible patients received disease-modifying antirheumatic drugs (DMARDs) and were divided into two groups: group A received 50,000 IU of vitamin D once a week; while group B received conventional DMARDs without vitamin D supplementation. The groups were monitored for 12 weeks.ResultsThe study included 68 RA patients, with the majority being female (75%). There were no significant differences in parameters such as age, sex, duration of illness, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), calcium, and vitamin D levels, as well as DAS28 (Disease Activity Score with 28-joint count) and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) levels between these two groups at baseline. After 12 weeks, group A showed a significant improvement in mean vitamin D levels and FACIT-F scores compared to group B. The increase in vitamin D levels in group A (24.21 ±4.81 nmol/l) was higher than that in group B (5.76 ±3.36 nmol/l). Furthermore, the FACIT-F score in group A was in the normal range (mean: 39.36 ±6.15), whereas group B still exhibited “abnormal” FACIT-F < 27.75 ±4.41. Correlation analysis indicated a positive correlation between FACIT-F and vitamin D levels, suggesting that higher vitamin D levels were associated with improved fatigue. Additionally, a weak inverse correlation was observed between DAS28 and vitamin D levels though the difference was not statistically significant (p > 0.05). Finally, the correlation between DAS28 and FACIT-F was positive (R = 0.557, p = 0.000).ConclusionsThe results of the recent study indicated that vitamin D3 (50,000 IU of cholecalciferol) supplementation had a positive impact in RA patients compared to conventional DMARDs drugs, as was clear from the significant FACIT-F.

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“…Autoimmune diseases can be roughly divided into organ-specific and systemic diseases, based both on the extent of their involvement and the type of autoantibodies present in the patients (Harsini & Rezaei, 2023;Karsdal et al, 2021;Lenti et al, 2022). In organ-specific autoimmune diseases, only specific cell types within an organ system are affected, such as thyroid gland cells in Graves' disease and Hashimoto's disease.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study on Total Glucoside of Peony (TGP) Administration in Organ-Specific Autoimmune Diseases at Prof. dr. R. D. Kandou Hospital, Indonesia

Mongdong,

Datau,

Surachmanto

et al. 2024

AJESH

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Autoimmune diseases are a diverse group of conditions characterized by immune disturbances that cause aberrant B cell and T cell reactivity to normal constituents of the host. These diseases can involve essentially any organ system and affect individuals of any age, with a much greater prevalence among women. Although certain mechanisms unite these conditions into a single category, the clinical manifestations of autoimmune disease are highly varied. This research is an original and interventional study. It is a preliminary with analytic observational. The design is “the one group pre-test – post-test design”. This study was conducted at RSUP Prof. dr. R. D. Kandou over a six-month period from July 2016 to December 2016. The study included patients diagnosed with Graves’ disease, Hashimoto’s disease, and aplastic anemia, who were diagnosed based on their medical history, physical examination, and diagnostic workups. This study also aimed to evaluate the improvement in clinical symptoms within the Aplastic Anemia group, tracking the number of complaints reported each week. Four patients were included in the study, each receiving individualized basic therapy.

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Autoimmune diseases

Cited by 6 publications

References 1,097 publications

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients

Preliminary Study on Total Glucoside of Peony (TGP) Administration in Organ-Specific Autoimmune Diseases at Prof. dr. R. D. Kandou Hospital, Indonesia

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