“…Lastly, the findings described in this report add to a growing literature implicating T lymphocyte in brain function, including learning 40 , 41 social behavior 42 , 43 and neurodegeneration in the setting of neuronal injury 44 , 45 . In this manner, it is conceivable that other systemic conditions involving T lymphocytes, such as eczema 26 , 46 , 47 , rheumatoid arthritis 48 , 49 , and diabetes 50 , 51 , may similarly impact gliomagenesis through overlapping or related mechanisms. Defining the molecular etiologies underlying how these T cell-mediated systemic conditions influence brain function and nervous system disease pathogenesis may also reveal unique immunomodulatory treatment strategies for neurological disorders.…”