Autoimmune diseases in coeliac disease: effect of gluten exposure

Ouaka-Kchaou, Asma; Ennaifer, Rym; Elloumi, Héla; Gargouri, Dalila; Hefaiedh, Rania; Kochlef, Asma; Romani, Malika; Kilani, Afef; Kharrat, Jamel; Ghorbel, Abdeljabbar

doi:10.1177/1756283x08096612

Cited by 13 publications

(10 citation statements)

References 12 publications

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“…Also, Ouaka-Kchaou et al showed that duration of the disease was longer at a significant level in CD patient accompanied by AID. They also determined that strict dietary compliance was 46% in the AID-accompanied group, and 67% in the group without AID 21…”

Section: Discussionmentioning

confidence: 99%

Association of autoimmune diseases with celiac disease and its risk factors

Kayar

Dertli²

2019

Pak J Med Sci

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Objectives:Autoimmune Diseases (AIDs) are detected in celiac patients. Our purpose was to determine the AIDs that are associated with celiac disease and related risk factors in the Turkish population.Methods:The study included 230 celiac patients who were diagnosed and followed-up in our clinics between 2015-2019. All AIDs that accompanied the celiac disease were recorded, and their association with risk factors was analyzed.Results:The mean age of the patients was 35.6±10.6 years (age range:18-72). A total of 58(25.2%) patients were male and the mean age at onset of disease was 29.1±6.5 years. The duration of disease follow-up was 6.5±4.6 years. One hundred and twenty two (53%) patients were on a strict diet, and 72(31.3%) patients had accompanying AID. Hashimoto thyroiditis was found in 39(17%) patients, asthma in 16(7%) patients as the most common comorbidities. There was a significant relation between AID and female gender, age of diagnosis being <40 years, duration of disease, non-GIS symptoms at the time of admission, and non-employment status.Conclusion:Screening other AIDs in celiac patients are important, especially in individuals who have risk factors. Considering that many AIDs may develop in the future despite dietary compliance, patients should be followed with a multidisciplinary approach.

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Section: Discussionmentioning

confidence: 99%

Association of autoimmune diseases with celiac disease and its risk factors

Kayar

Dertli²

2019

Pak J Med Sci

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“…Since then, other studies have been conducted to further explore the association between gluten exposure in CD patients and the development of these disorders [ 188 , 198 , 199 , 200 ]. Three of the studies revealed that the risk for developing other autoimmune diseases does not appear to be significantly impacted by the duration of gluten exposure in CD patients [ 188 , 198 , 199 ]. Cosnes et al [ 200 ], on the other hand, reported a possible protective effect of the gluten-free diet.…”

Section: Gluten-related Disordersmentioning

confidence: 99%

“…Cosnes et al [ 200 ], on the other hand, reported a possible protective effect of the gluten-free diet. As many of these studies are based on retrospective data [ 198 , 199 , 200 ], prospective research in this area is advised.…”

Section: Gluten-related Disordersmentioning

confidence: 99%

A Review on the Gluten-Free Diet: Technological and Nutritional Challenges

2018

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Consumers, food manufacturers and health professionals are uniquely influenced by the growing popularity of the gluten-free diet. Consumer expectations have urged the food industry to continuously adjust and improve the formulations and processing techniques used in gluten-free product manufacturing. Health experts have been interested in the nutritional adequacy of the diet, as well as its effectiveness in managing gluten-related disorders and other conditions. In this review, we aim to provide a clear picture of the current motivations behind the use of gluten-free diets, as well as the technological and nutritional challenges of the diet as a whole. Alternative starches and flours, hydrocolloids, and fiber sources were found to play a complex role in mimicking the functional and sensory effects of gluten in gluten-free products. However, the quality of gluten-free alternatives is often still inferior to the gluten-containing products. Furthermore, the gluten-free diet has demonstrated benefits in managing some gluten-related disorders, though nutritional imbalances have been reported. As there is limited evidence supporting the use of the gluten-free diet beyond its role in managing gluten-related disorders, consumers are urged to be mindful of the sensorial limitations and nutritional inadequacies of the diet despite ongoing strategies to improve them.

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“…Our IgG positive group excluded IgA positive specimens so as to prevent using possible celiac patients in the group. The link between Celiac disease and additional extraintestinal disorders has been well-established [25][26][27]. What hasn't been fully discussed is the link between non-celiac gluten sensitivity (NCGS) and autoimmunity.…”

Section: Gluten Family Proteinsmentioning

confidence: 99%