Autoimmune endocrinopathy associated with diabetes insipidus

Bhan, G.L.; O’Brien, Timothy

doi:10.1136/pgmj.58.677.165

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…These antibodies were also detected in one patient with other autoimmune endocrine diseases without DI, who subsequently developed partial central DI . A similar case was described in the same year by Bhan and O'Brien (1982), who, however, did not look for AVP-cell-Ab. Thus, the appearance of AVP-cell-Ab in patients without DI could signal a high risk of development of this disease and call for functional endocrine monitoring of these patients.…”

Section: Discussionsupporting

confidence: 54%

Detection of vasopressin cell antibodies in some patients with autoimmune endocrine diseases without overt diabetes insipidus

Bellis

Bizzarro

Paglionico

et al. 1994

Clinical Endocrinology

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AVP cell antibodies can be shown in some patients with endocrine autoimmune disease without diabetes insipidus and can sometimes be associated with findings of partial posterior pituitary dysfunction. This suggests that clinical diabetes insipidus could be preceded by a long subclinical period characterized only by the occurrence of AVP-cell-Ab in the sera associated or followed by alterations in functional tests. Longitudinal studies are needed to confirm this hypothesis.

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Section: Discussionsupporting

confidence: 54%

Detection of vasopressin cell antibodies in some patients with autoimmune endocrine diseases without overt diabetes insipidus

Bellis

Bizzarro

Paglionico

et al. 1994

Clinical Endocrinology

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“…Organ-specific autoimmune disorders are developing in certain individuals, and many families have become victims of such syndromes ( 1 ). Persistent hyperglycemia can affect thyroid gland activity, one of the important endocrine systems in animals ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…Many diabetic individuals have also been extensively reported to have reproductive alterations ( 6 ), the relationship between the two endocrine disorders has been described in various groups during the past two decades ( 7 – 9 ). It is reported that deiodinases and thyroid receptors are presented in the testis, and thousands of novel genes in testes that are regulated by T3 ( 1 , 3 ). It certainly affects the glucose metabolism which is critical in the testis function.…”

Section: Introductionmentioning

confidence: 99%

Effects of hyperthyroidism and diabetes mellitus on spermatogenesis in peri- and post-pubertal mice

Shi,

Korejo,

Kamboh

et al. 2023

Front. Endocrinol.

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IntroductionDiabetes and thyroid dysfunction often co-exist. One autoimmune disorder always invites another and it has been reported that such co-morbid ailments always become detrimental to the health of the patients.Materials and methodsIn our previous work, we elucidated the interactions of diabetes and hypothyroidism on testicular development and spermatogenesis. However, the present study illuminates the interface between diabetes and hyperthyroidism, where 16 ICR pregnant primiparous mice were used and subsequently 48 male pups were randomly selected (n=12/group) and separated into 4 groups: control (C), diabetic (D), diabetic + hyperthyroidism (DH) and hyperthyroidism (H).ResultsComputerized sperm analyses showed significant reductions in count by 20% and increases of 15% in D and H animals, respectively, vs. controls. However, rapid progressive sperm motility was significantly lower only in D (30%) compared with C mice. Our histomorphometric investigation depicted damaging effects on testicular and epididymal tissues; the stroma adjacent to the seminiferous tubules of the D mice revealed edematous fluid and unstructured material. However, in the epididymis, germ cell diminution contraction of tubules, compacted principal and clear cells, lipid vacuolization, atypical cellular connections, exfoliated epithelial cells, and round spermatids were conspicuous in DH mice.DiscussionCollectively, our experiment was undertaken to ultimately better recognize male reproductive disorders in diabetic-hyperthyroid patients.

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“…The co-existence of CDI and diabetes mellitus without inherited disorders [6,7] is rare. Co-existing CDI and type 1 diabetes mellitus have been reported in patients with polyglandular autoimmune syndrome [8]. Although the etiological links remain unclear, several cases of CDI with T2D [9][10][11][12][13][14] or diabetes mellitus of other etiologies [15][16][17][18] have been reported.…”

Section: Introductionmentioning

confidence: 99%

A 75-Year-Old Woman with a 5-Year History of Controlled Type 2 Diabetes Mellitus Presenting with Polydipsia and Polyuria and a Diagnosis of Central Diabetes Insipidus

Ohara¹,

Takada²,

Seki³

et al. 2022

Am J Case Rep

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Rare coexistence of disease or pathology Background:Central diabetes insipidus (CDI) is a rare disorder characterized by large volumes of dilute urine because of a lack of antidiuretic hormone. Co-existing CDI and diabetes mellitus without inherited disorders such as Wolfram syndrome are rare. It is both important and challenging to diagnose this combination because the 2 conditions present with thirst, polydipsia, and polyuria. A few cases of CDI developing in patients with type 2 diabetes mellitus (T2D) have been reported. We report an unusual case of CDI that developed in an older patient with T2D. The aims of this report are to share the clinical course and discuss clues to the early diagnosis of CDI in T2D. Case Report:A 70-year-old Japanese woman developed T2D with hyperglycemia symptoms, including thirst, polydipsia, and polyuria. After starting medical treatment, the hyperglycemia and its symptoms improved. The glycated hemoglobin level decreased from 9% to 6%. However, 5 years later (at 75 years of age), she re-exhibited thirst, polydipsia, and polyuria despite stable glycemic control. Her urine volume was large (6.3 L/day). A urine glucose test was negative. The plasma osmolality was high (321 mOsm/kg), while the urinary osmolality was low (125 mOsm/kg). A significant increase in urinary osmolality following vasopressin administration indicated a diagnosis of CDI. Desmopressin therapy effectively relieved the symptoms. Conclusions:This case highlights the need to consider CDI as a rare but important comorbid disorder in patients with diabetes mellitus, including T2D, particularly those presenting with thirst, polydipsia, and polyuria despite wellcontrolled glycemia.

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Autoimmune endocrinopathy associated with diabetes insipidus

Abstract: A case is described in which diabetes insipidus was associated with hypopituitarism, insulin-independent diabetes mellitus, pernicious anaemia and circulating antibodies to the thyroid gland, adrenal gland and the pancreatic islet cells.

Cited by 11 publications

References 3 publications

Detection of vasopressin cell antibodies in some patients with autoimmune endocrine diseases without overt diabetes insipidus

Detection of vasopressin cell antibodies in some patients with autoimmune endocrine diseases without overt diabetes insipidus

Effects of hyperthyroidism and diabetes mellitus on spermatogenesis in peri- and post-pubertal mice

A 75-Year-Old Woman with a 5-Year History of Controlled Type 2 Diabetes Mellitus Presenting with Polydipsia and Polyuria and a Diagnosis of Central Diabetes Insipidus

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