Autoimmune enteropathy and nephropathy with circulating anti-epithelial cell antibodies

Colletti, Richard B.; Guillot, Ann; Rosen, Seymour; Bhan, Atul K.; Hobson, Christine; Collins, A. Bernard; Russell, Gary J.; Winter, Harland S.

doi:10.1016/s0022-3476(05)82195-x

Cited by 56 publications

(48 citation statements)

References 18 publications

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“…In 1982, Walker-Smith et al (6) first described circulating autoantibodies against the gut epithelium in an 18-month-old boy with chronic diarrhea, failure to thrive, and small intestinal enteropathy. Since then, several additional cases of autoimmune enteropathy have been reported (25)(26)(27)(28). Although we could not finely make the diagnosis of autoimmune enteropathy because of the lack of diagnostic modalities including gut epithelial cell autoantibodies (6,25,(28)(29)(30)(31)(32), at least some of the patients in this study might have had autoimmune enteropathy because all cases in the epithelial dysplasia group were unresponsive to elemental milk, dependent on PN, and had considerable villous atrophy.…”

Section: Discussionmentioning

confidence: 79%

Protracted Diarrhea: Results of the Five-year Survey in a Tertiary Hospital in Korea

2001

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The syndrome of protracted diarrhea (PD) includes several diseases with diverse etiologies. This study was conducted to characterize the spectrum of causes, clinical manifestations, and the outcomes of PD. A retrospective analysis of the clinical and pathological findings was performed on 25 patients with diarrhea starting within the first 2 yr of life and a requirement of parenteral nutrition (PN). According to the intestinal histopathology, patients were classified into four groups: immune enteropathy (12 cases), lymphangiectasia (6 cases), epithelial dysplasia (5 cases), and unclassified (2 cases). All patients with epithelial dysplasia had earlier onset of diarrhea and longer duration of PN than those in the other groups. Three patients (12%) had an evidence of a familial condition. Five patients (three with microvillous inclusion disease and two with immune enteropathy) died. Sixteen patients recovered, and three (two with primary lymphangiectasia and one with microvillous inclusion disease) still had diarrhea. One patient underwent intestinal transplantation for tufting enteropathy. In conclusion, infants with PD should be referred to specialized centers where advanced diagnostic and therapeutic facilities are available, because histological analysis is critical for the diagnosis of PD, and PN or intestinal transplantation is the only therapeutic option in a subset of cases.

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Section: Discussionmentioning

confidence: 79%

Protracted Diarrhea: Results of the Five-year Survey in a Tertiary Hospital in Korea

2001

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“…Une caractérisation par Western blot a montré que les autoantigènes sont de 55 [17] ou 75 kDa [18,19] L'autoantigène de 75 kDa est exprimé dans l'intestin grêle, le côlon, le pancréas et les reins [20] . Avec le traitement (envisagé plus bas), les titres d'anticorps anti-entérocytes circulants diminuent ou disparaissent progressivement et totalement, tandis que la situation clinique s'améliore.…”

Section: Observations Anatomopathologiquesunclassified

“…Avec le traitement (envisagé plus bas), les titres d'anticorps anti-entérocytes circulants diminuent ou disparaissent progressivement et totalement, tandis que la situation clinique s'améliore. Les titres des autoanticorps systémiques permettent donc de suivre la réponse aux traitements [17] .…”

Section: Observations Anatomopathologiquesunclassified

Entéropathies immunes et auto-immunes

Sherman

Cutz

Goulet³

2006

Ann Nestlé [Fr]

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“…allmählich aber vollständig abgebaut, wobei sich der klinische Zustand verbessert. Es bietet sich daher an, die Blutspiegel der systemischen Autoantikörper zu beobachten, die ein objektiver Massstab dafür sind, ob eine klinische Intervention anspricht oder nicht [17] .…”

Section: Autoantikörperunclassified