Autoimmune gastritis serological biomarkers in gastric cancer patients

Abstract

The role of autoimmunity in the pathogenesis of gastric cancer remains controversial. We studied antiparietal cell antibody (anti-PCA) and anti-intrinsic factor antibody (anti-IFA) levels and their associations with pepsinogen I/pepsinogen II levels in patients with gastric adenocarcinoma compared to a control group with mild or no atrophy of the stomach mucosa. Plasma levels of anti-PCA and anti-IFA were measured by ELISA (Inova Diagnostics Inc, San Diego, California, USA). The cutoff value for anti-PCA and anti-IFA positivity was ≥25 units. Altogether 214 patients (126 men, 88 women, median age 64.46, range: 35–86) with confirmed gastric adenocarcinoma and 214 control cases paired for age and sex were included in the study. Positive anti-PCA was present in 22 (10.3%) gastric cancer patients and controls (P ≥ 0.999); positive anti-IFA in 6 (2.8%) and 4 (1.9.%), P < 0.232, respectively. We did not find significant differences in anti-PCA and anti-IFA positivity between gastric cancer patients and the control group; further investigation is required to better understand the potential involvement of autoimmune gastritis in the development of gastric cancer.

Autoimmune Atrophic Gastritis: A Clinical Review

“…Serologic markers of AAG include anti-parietal cell antibodies and anti-intrinsic factor antibodies [30]. The sensitivity and specificity of anti-parietal cell antibodies for the diagnosis of AAG are 81% and 90%, respectively, whereas anti-intrinsic factor antibodies have poor sensitivity (27%) and high specificity (100%) [1].…”

“…Similar results were reported by another prospective cohort study aimed at evaluating the natural history of autoimmune gastritis in 498 patients with AAG at any stage. During the median follow-up time of 52 months, newly onset neoplastic complications occurred in 41/498 patients (8.5%); in particular, NETs [30] and epithelial dysplasia (18), but no cases of gastric adenocarcinoma, were reported [20]. Murine models showed that M2-macrophages are a pro-carcinogenic immune infiltrate that is crucial for the progression from metaplasia to dysplasia [61].…”

Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics

“…Потенциал АИГ как предракового заболевания требует дальнейшего изучения. P. Kriķe et al у пациентов с диагнозом аденокарциномы желудка не обнаружили более частого выявления антител к париетальным клеткам и к внутреннему фактору по сравнению с контрольной группой [17]. При длительном наблюдении за пациентами АИГ без инфекции H. pylori в анамнезе не было установлено повышения риска рака желудка по сравнению с контрольной группой, и авторы предполагают, что этот риск может быть ассоциирован именно с предшествующей или нераспознанной текущей инфекцией H. pylori [18].…”