Autoimmune Hæmolytic Anæmia in an Infant Treated by Thymectomy

Wilmers, MaryJ.; Russell, P.

doi:10.1016/s0140-6736(63)90623-8

Cited by 39 publications

(9 citation statements)

References 10 publications

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“…There is little to suggest that thymectomy in adult man leads to any impairment of immunological function. Although Wilmers and Russell [1963] have reported a case of auto-immune haemolytic anaemia that went into remission after thymectomy, Alarcon-Segovia et al [1963] have reported two cases of systemic lupus erythematosus following thymectomy for myasthenia gravis and Helyer and Howie [1963] in their study of the NZB/B1 strain of inbred mice showed that neonatal thymectomy does not prevent the spontaneous development of auto-immune halmolytic anaemia in these animals.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Auto‐immunity as a Disorder of Immunological Tolerance

Irvine

1964

Exp Physiol

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The immunological response to thyroid damage has been studied in the 101. thyrotoxic patients treated with radioactive iodine (1311). Patients who had positive titres of thyroid complement-fixing (CF) antibody in the sera before treatment invariably showed a rise in titre of this antibody commencing approximately 6 weeks after treatment but always falling to pre-treatment or lower levels after some months. Only in exceptional cases was there any formation of the thyroid CF antibody in patients who had negative thyroid CF tests before treatment; this was so even when the 1311 treatment was repeated on two, three or four occasions. In general, the change in thyroid CF titre was more pronounced than the change in titre of antibody to thyroglobulin.Although the epithelial cells of the human fectal thyroid are riclh in thyroid cytoplasmic antigen, the basement membrane is even more delicate than that noted in Hashimoto thyroiditis affecting the adult gland.A preliminary study has been made of the thymus in Hashimoto thyroiditis. Numerous germinal centres were observed in a thymic biopsy in one case and the radiological appearances of an enlarged thymus were noted in two others.These several findings are considered in terms of the possible meclhanisms of auto-inununity and the view is taken that formation of thyroid auto-antibodies is a result of a genetically determined disorder of immunological tolerance.

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Section: Discussionmentioning

confidence: 99%

Thyroid Auto‐immunity as a Disorder of Immunological Tolerance

Irvine

1964

Exp Physiol

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“…Wilmers & Russell (1963) reported that thymectomy had been carried out as a last resort on an infant aged 2 1 / 2 months who had been suffering from extremely severe AIHA. The infant went into remission approximately 1 month after the operation.…”

Section: Other Therapies That Have Been Triedmentioning

confidence: 99%

The immune haemolytic anaemias: a century of exciting progress in understanding

Dacie¹

2001

Br J Haematol

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“…Eosinophilia and plasmacytosis in the thymus are features of some autoimmune diseases, e.g. systemic lupus erythematosus [3] and haemolytic anaemia [10,26]. We do not know whether the transplanted CTF can cause an autoimmune process; transplants into humans for periods up to 18 months have not been associated with detectable autoaggression [5].…”

Section: Figs 3(b) and 3(c)mentioning

confidence: 99%

Transplantation of Cultured Thymic Fragments I. Morphologic and Technical Considerations

1978

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Thymic fragments were maintained in organ culture until egress or deterioration of the leucocyte component was near completion. These depopulated cultured thymic fragments were then implanted into immunologically competent mouse recipients. Acute immunologic rejection was not observed in mice given cultured thymic allografts. If the organ culture period was approximately 2 weeks, lymphoid repopulation and newly developed Hassall's corpuscles were observed 7-10 weeks after implantation. If the initial culture period was extended to 3 weeks, transplanted fragments developed as unusual repopulation pattern, characterized by eosinophils, macrophages and plasma cells. This finding could be interpreted as a protracted allograft rejection or, more likely, a loss of ability of the thymic epithelium to attract or differentiate the types of precursors usually attracted to the normal gland. When cultured and non-cultured tissues were simultaneously transplanted in a single recipient, the non-cultured tissue was acutely rejected and became fibrous, while the cultured thymus assumed the appearance of a normal lymphoid organ without any neighbouring inflammatory reaction.

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Autoimmune Hæmolytic Anæmia in an Infant Treated by Thymectomy

Cited by 39 publications

References 10 publications

Thyroid Auto‐immunity as a Disorder of Immunological Tolerance

Thyroid Auto‐immunity as a Disorder of Immunological Tolerance

The immune haemolytic anaemias: a century of exciting progress in understanding

Transplantation of Cultured Thymic Fragments I. Morphologic and Technical Considerations

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