Autoimmune Hemolytic Anemia and HLA-DQ6

Nomura, Shosaku; Okamae, Fumiko; Matsuzaki, Tatsunori; Ishida, Tomoko; Fukuhara, Shirou

doi:10.3109/08916939808993845

Cited by 4 publications

(2 citation statements)

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“…Human patients with AIHA have been reported to have increased frequencies of the HLA class I alleles, B8, (36) and B27 (37), and also reduced frequency of HLA‐DQ6 (38, 39). There are no other reports of studies on HLA class II for human AIHA, so these class I associations may reflect linkage with other MHC genes.…”

Section: Introductionmentioning

confidence: 99%

Association of a common dog leucocyte antigen class II haplotype with canine primary immune‐mediated haemolytic anaemia

et al. 2006

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Immune-mediated haemolytic anaemia (IMHA) is the commonest immune-mediated disease of the dog, representing a major health concern to this species. The aim of this investigation was to determine whether genetic susceptibility to IMHA is associated with genes of the canine major histocompatibility complex (MHC; dog leucocyte antigen system, DLA). Samples were collected from 108 dogs with primary idiopathic, Coombs' positive IMHA. This diseased population was subdivided on the basis of Coombs' test results into two groups: 1) dogs with dominant warm-reactive immunoglobulin (Ig) G haemagglutinins and (2) dogs with an additional or dominant cold-reactive IgM haemagglutinin. The DLA class II alleles and haplotypes of the diseased population were characterised, and these data were compared with those derived from a breed-matched control cohort and a much larger group of DLA-typed dogs. Two haplotypes were increased in the patient group: DLA-DRB1*00601/DQA1*005011/DQB1*00701 (in the group with warm-reactive IgG haemagglutinins only) and DLA-DRB1*015/DQA1*00601/DQB1*00301 (in both groups, but more so in the group with cold-reactive IgM haemagglutinins). One haplotype, DLA-DRB1*001/DQA1*00101/DQB1*00201, was decreased in the total patient group, but this decrease was limited to the warm-reactive IgG haemagglutinins group, and it was actually increased in the cold-reactive IgM haemagglutinins group. A second haplotype, DLA-DRB1*015/DQA1*00601/DQB1*02301, was also decreased in the total patient group, and this decrease was found in both subgroups. In addition, all haplotypes carrying DLA-DRB1*001 were significantly increased in the cold-reactive IgM haemagglutinins group. When the overall patient group was divided on the basis of individual breeds with more than six animals represented, each of the haplotypes could be shown to be implicated in one of the breeds. Thus, it was apparent that different breeds had different MHC associations with canine IMHA, which is similar to the observation that different human ethnic groups can have different HLA associations with the same immune-mediated disease.

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Section: Introductionmentioning

confidence: 99%

Association of a common dog leucocyte antigen class II haplotype with canine primary immune‐mediated haemolytic anaemia

et al. 2006

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“…HLA-DQ6 has a negative correlation with the degree of hemolysis. [ 27 ] Rhesus (Rh) polypeptides are the most common targets for pathogenic autoantibodies in patients with warm AIHA, while in those with cold AIHA, the Ii blood group system is the most common target. The postulated mechanisms of the abnormal autoantibody producing including an immune response toward some cryptic antigens and/or a molecular mimicry with a cross-reactivity between external antigens and autoantigens, which is likely in RP.…”

Section: Discussionmentioning

confidence: 99%

Case report of mixed-type autoimmune hemolytic anemia in a patient with relapsing polychondritis

Luo

Zuo

et al. 2018

Medicine

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Rationale:Relapsing polychondritis (RP) is a rare autoimmune-related disease and may be associated with other autoimmune diseases.Patient concerns: Here we reported a case of RP patients with mixed-type AIHA. The patient was diagnosed with RP in March 2008 which was treated and the patient was in stable condition. Laboratory data revealed progressive decrease in hemoglobin during her hospitalization due to pulmonary infection in 2016. Positive Coombs’ test and moderate titer of anti-cold agglutinin was detected.Diagnosis:Mixed-type AIHA was diagnosed as a comorbidity in this case given the circumstance that her RP was stable and low-dose oral corticosteroids was enough to maintain remission.Interventions:The patient was treated with intravenous immunoglobulin and steroids.Outcomes:The patient's body temperature dropped and hemoglobin levels rose in 2 weeks.Lessons:Reports of RP patients with autoimmune hemolytic anemia (AIHA) are extremely rare and cases with the mixed-type AIHA has not been reported. Here we describe a case of RP with mixed-type AIHA which was considered as a comorbidity rather than a complication.

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Helper T cells in antibody-mediated, organ-specific autoimmunity

Elson

Barker

2000

Current Opinion in Immunology

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Autoimmune Hemolytic Anemia and HLA-DQ6

Cited by 4 publications

References 4 publications

Association of a common dog leucocyte antigen class II haplotype with canine primary immune‐mediated haemolytic anaemia

Association of a common dog leucocyte antigen class II haplotype with canine primary immune‐mediated haemolytic anaemia

Case report of mixed-type autoimmune hemolytic anemia in a patient with relapsing polychondritis

Helper T cells in antibody-mediated, organ-specific autoimmunity

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