Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy

Felemban, Afaf; Rashidi, Zuha A.; Almatrafi, Musab H.; Alsahabi, Jawaher

doi:10.15537/smj.2019.4.24l07

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Although there have been case reports of AIHA associated with mature cystic teratoma in recent years [ 4 – 6 ], the exact mechanism between mature cystic teratoma and AIHA remains elusive. However, several theories have been proposed regarding the etiology of secondary AIHA associated with mature cystic teratomas, including (1) immune responses against abnormal RBCs; (2) changes in RBC antigenicity caused by tumor-derived substances, like haptens; and (3) in situ antibody production within the tumor tissue, possibly by lymphoid cells [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature

Nato,

Nagaharu,

Itoh

et al. 2024

Case Reports in Obstetrics and Gynecology

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Background. Autoimmune hemolytic anemia (AIHA) associated with solid tumors such as mature cystic teratomas is rare and poorly understood. Here, we report a successfully treated case of secondary AIHA in a mature cystic teratoma containing antibodies against red blood cells. Case description. A 22-year-old woman was referred to our hospital with progressive anemia. Laboratory findings revealed hemolysis with a positive direct and indirect antiglobulin test. Imaging studies identified a left ovarian mass, suspected to be a mature cystic teratoma, which was later confirmed by histopathology after laparoscopic oophorocystectomy. The patient was treated with prednisolone, resulting in improved anemia. To examine the relationship between the tumor and AIHA, an indirect antiglobulin test was performed on the tumor contents. Stronger aggregations were observed at any concentration diluted by 10 times from 10 to 10,000 times of the tumor contents compared to the patient’s serum. Additionally, immunofixation electrophoresis of the tumor contents revealed the presence of monoclonal immunoglobulin G-κ. Conclusion. The presence of monoclonal IgG-κ in the tumor suggests intratumoral antibody production as a possible mechanism. Further research is necessary to elucidate the pathogenic relationship between such tumors and AIHA. The report also highlights the importance of considering secondary AIHA in patients with unexplained anemia and solid tumors.

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Section: Discussionmentioning

confidence: 99%

Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature

Nato,

Nagaharu,

Itoh

et al. 2024

Case Reports in Obstetrics and Gynecology

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“…AIHA is rare during pregnancy, and the exact incidence has not been reported[ 9 , 10 ]. It has been reported that ovarian teratomas were suggested as a possible trigger of AIHA in pregnant and non-pregnant patients[ 11 ]. The diagnosis is generally based on the presence of anemia along with signs of hemolysis such as reticulocytosis, low haptoglobin, increased LDH, elevated indirect bilirubin, and a positive DAT.…”

Section: Discussionmentioning

confidence: 99%

Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient with β-thalassemia minor during pregnancy: A case report

Zhou¹,

Ding²,

Zhang³

et al. 2022

WJCC

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BACKGROUND Severe refractory anemia during pregnancy can cause serious maternal and fetal complications. If the cause cannot be identified in time and accurately, blind symptomatic support treatment may cause serious economic burden. Thalassemia minor pregnancy is commonly considered uneventful, and the condition of anemia rarely progresses during pregnancy. Autoimmune hemolytic anemia (AIHA) is rare during pregnancy with no exact incidence available. CASE SUMMARY We report the case of a 30-year-old β-thalassemia minor multiparous patient experiencing severe refractory anemia throughout pregnancy. We monitored the patient closely, carried out a full differential diagnosis, made a diagnosis of direct antiglobulin test-negative AIHA, and treated her with prednisone and intravenous immunoglobulin. The patient gave birth to a healthy full-term baby. CONCLUSION Coombs-negative AIHA should be suspected in cases of severe hemolytic anemia in pregnant patients with and without other hematological diseases.

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“…The basic treatment for TTP and complement-mediated HUS is the exchange of plasma. Delivery is the basic treatment for other pregnancy-related thrombotic microangiopathies (HELLP and preeclampsia) that occur during the third trimester [20].…”

Section: Treatmentmentioning

confidence: 99%

Anemia during Pregnancy and Its Prevalence

Zulkifal¹,

Sarwar²,

Saddique³

et al. 2022

Primary Health Care

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Anemia is a serious health issue throughout the world affecting both sexes of any age group. This nutritional disease is more common among the pregnant women of developing countries, where it is a major cause of maternal death and negative outcome of pregnancy. Among all anemic types, IDA is most prevalent one and is comprises of about 95% of all anemic cases around the world. In many developing countries it is more common in women of low socio-economic background and with no record of antenatal checkup. There is need for further health educational programs to overcome anemia especially for pregnant females.

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Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy

Cited by 4 publications

References 5 publications

Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature

Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature

Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient with β-thalassemia minor during pregnancy: A case report

Anemia during Pregnancy and Its Prevalence

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