Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy

Felemban, Afaf; Rashidi, Zuha A.; Almatrafi, Musab H.; Alsahabi, Jawaher

doi:10.15537/smj.2019.4.24107

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Частота цієї патології стано вить 0,83-3 випадки на 100 000 на рік, а поши реність -17 випадків на 100 000 населення [7,19]. Комбінація вагітності з АІГА зустріча ється з імовірною частотою від 1 випадку на 50 000 вагітностей [5,11,17] до 1 випадку на 140 000 вагітностей [7].…”

Section: ен наумчикunclassified

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A case of pregnancy complicated with Evance syndrome and heparin-induced thrombocytopenia

Naumchik¹

2021

UJPP

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The simultaneous development of autoimmune hemolytic anemia and immune thrombocytopenia is known as Evans syndrome. This pathology is extremely rare during pregnancy, requires careful differential diagnosis and is associated with a high risk of hemorrhagic and thromboembolic complications. Treatment approaches for autoimmune hemolytic anemia and immune thrombocytopenia are similar, but in the case of autoimmune hemolytic anemia, thromboprophylaxis is mandatory. Heparin-induced thrombocytopenia is a serious adverse event of anticoagulation. One presents with a decrease in platelets but a paradoxical increase in thrombotic risk and mandates switching of the anticoagulant agent to a non-heparin one. Clinical case. We describe the case of pregnancy complicated with Evans syndrome and development of heparin-induced thrombocytopenia at 28 weeks. Treatment of the underlying disease was effective on the use of first-line therapy. Fondaparinux and vitamin K antagonist (warfarin) have been used to treat heparin-induced thrombocytopenia. Monitoring of the fetal condition is carried out with careful control of Doppler ultrasound of the middle cerebral artery. Successful change of anticoagulant, close surveillance and carefully selected therapy allowed to achieve a successful termination of pregnancy. A healthy female newborn with body weight 2450 g, 8–8 Apgar scores was vaginally delivered uneventful at the 38th week. There were neither neonatal thrombocytopenia nor anemia. During the year after birth, the woman's condition is not worse, the child develops according to age. An analysis of similar cases of pregnancy from the literature is described. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: thrombocytopenia, hemolytic anemia, pregnancy, Evans syndrome, heparin-induced thrombocytopenia.

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Section: ен наумчикunclassified

“…Ще одним чинником ризику АІГА вважа ються доброякісні тератоми яєчника з потен ційною стійкістю до лікування кортикостерої дами [5,16,19].…”

Section: ен наумчикunclassified

A case of pregnancy complicated with Evance syndrome and heparin-induced thrombocytopenia

Naumchik¹

2021

UJPP

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Ovarian and non-ovarian teratomas: a wide spectrum of features

et al. 2020

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Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient with β-thalassemia minor during pregnancy: A case report

Zhou¹,

Ding²,

Zhang³

et al. 2022

WJCC

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BACKGROUND Severe refractory anemia during pregnancy can cause serious maternal and fetal complications. If the cause cannot be identified in time and accurately, blind symptomatic support treatment may cause serious economic burden. Thalassemia minor pregnancy is commonly considered uneventful, and the condition of anemia rarely progresses during pregnancy. Autoimmune hemolytic anemia (AIHA) is rare during pregnancy with no exact incidence available. CASE SUMMARY We report the case of a 30-year-old β-thalassemia minor multiparous patient experiencing severe refractory anemia throughout pregnancy. We monitored the patient closely, carried out a full differential diagnosis, made a diagnosis of direct antiglobulin test-negative AIHA, and treated her with prednisone and intravenous immunoglobulin. The patient gave birth to a healthy full-term baby. CONCLUSION Coombs-negative AIHA should be suspected in cases of severe hemolytic anemia in pregnant patients with and without other hematological diseases.

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Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy

Cited by 6 publications

References 9 publications

A case of pregnancy complicated with Evance syndrome and heparin-induced thrombocytopenia

A case of pregnancy complicated with Evance syndrome and heparin-induced thrombocytopenia

Ovarian and non-ovarian teratomas: a wide spectrum of features

Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient with β-thalassemia minor during pregnancy: A case report

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