Autoimmune hemolytic anemia in pregnancy: a challenge for maternal and fetal follow-up

Maroto, Anna; Martinez-Diago, Clara; Sagüés, Miguel; Borrell, A.; Bonmatí, Alexandra; Teixidor, Mireia; Adrados, Cristina; Torrent, Sara; Álvarez, Elena

doi:10.1080/14767058.2020.1732344

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…Each type of AIHA can be further classified based on the presence of underlying diseases [12]. A previous report by Maroto et al demonstrated that warm, IgG-mediated AIHA exhibited normal clinical findings and did not result in adverse perinatal outcomes [19,20]. In this patient, Warm AIHA secondary to SLE remains a possibility.…”

Section: Resultsmentioning

confidence: 69%

Untitled

2023

J. Med. Chem. Sci.

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Section: Resultsmentioning

confidence: 69%

Untitled

2023

J. Med. Chem. Sci.

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“…The incidence of AIHA in the general population is 1/100.000[ 8 ]. AIHA is rare during pregnancy, and the exact incidence has not been reported[ 9 , 10 ]. It has been reported that ovarian teratomas were suggested as a possible trigger of AIHA in pregnant and non-pregnant patients[ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient with β-thalassemia minor during pregnancy: A case report

Zhou¹,

Ding²,

Zhang³

et al. 2022

WJCC

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BACKGROUND Severe refractory anemia during pregnancy can cause serious maternal and fetal complications. If the cause cannot be identified in time and accurately, blind symptomatic support treatment may cause serious economic burden. Thalassemia minor pregnancy is commonly considered uneventful, and the condition of anemia rarely progresses during pregnancy. Autoimmune hemolytic anemia (AIHA) is rare during pregnancy with no exact incidence available. CASE SUMMARY We report the case of a 30-year-old β-thalassemia minor multiparous patient experiencing severe refractory anemia throughout pregnancy. We monitored the patient closely, carried out a full differential diagnosis, made a diagnosis of direct antiglobulin test-negative AIHA, and treated her with prednisone and intravenous immunoglobulin. The patient gave birth to a healthy full-term baby. CONCLUSION Coombs-negative AIHA should be suspected in cases of severe hemolytic anemia in pregnant patients with and without other hematological diseases.

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“…The antibodies are typically classified into warm (typically IgG isotype), cold (typically IgM isotype) or mixed (IgG and IgM isotype) according to the optimum temperature for haemolysis. 2 As IgG crosses the placenta, warm AIHA has the potential to cause severe anaemia in the fetus or neonate. 7 AIHA can be primary or secondary to malignancy, infections, immunodeficiency and medications.…”

Section: Discussionmentioning

confidence: 99%

“…1 The incidence of autoimmune haemolytic anaemia (AIHA) in the general population is 1 in 100,000 however there are only limited reports in pregnancy. 2 Typically, the hallmark feature is a positive direct antiglobulin test (DAT). 5-10% of AIHA cases, however, are associated with a negative DAT therefore it is important that a diagnosis of AIHA is not excluded on this basis.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy‐associated haemolytic anaemia: A cause not to be forgotten

Creeper

Graham

2021

Obstet Med

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Anaemia in pregnancy is common, however, only a few cases of pregnancy-associated autoimmune haemolytic anaemia have been documented. Typically, such cases involve a positive direct antiglobulin test and have the potential to cause haemolytic disease of the fetus and newborn. Rarely, no autoantibodies are detected. We report two cases of direct antiglobulin test negative haemolytic anaemia occurring in multiparous women with no cause found. Both women had a haematological response to corticosteroid therapy and delivery.

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Autoimmune hemolytic anemia in pregnancy: a challenge for maternal and fetal follow-up

Cited by 8 publications

References 13 publications

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Direct antiglobulin test-negative autoimmune hemolytic anemia in a patient with β-thalassemia minor during pregnancy: A case report

Pregnancy‐associated haemolytic anaemia: A cause not to be forgotten

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