Autoimmune Hemolytic Anemia Induced by Adalimumab

Harada, Yukinori; Yamamoto, Hiroaki; Sato, Midori; Kodaira, Mutsuki; Kono, Tsunesuke

doi:10.2169/internalmedicine.55.5980

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Certain therapies used in the treatment of IBD are an additional factor that can cause anaemia. These include 5-sulfasalazine derivatives (20) , azathioprine (21) , cyclosporine (22) , infliximab (23) , and adalimumab (24) . Therefore, blood cell counts should be monitored periodically during treatment with these agents.…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Chronic anaemia in children as a manifestation of gastrointestinal disorders

Wronecka¹,

Pac-Kożuchowska²,

Mroczkowska-Juchkiewicz³

et al. 2022

Pediatr Med Rodz

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Anaemia is a common problem encountered by paediatricians and general practitioners in the paediatric population. If left untreated, it can lead to serious health consequences, slower development and cognitive impairment. Therefore, it is extremely important to identify its cause and implement appropriate treatment. Since iron deficiency is the most common cause of anaemia, oral iron supplementation at appropriate doses should be used as a first step. However, anaemia may be secondary and often the only symptom of pathological processes in the body. It very often accompanies gastrointestinal diseases, which cause impaired absorption of hematopoietic elements, blood loss through the gastrointestinal tract and dysregulation of iron metabolism accompanying chronic diseases. Therefore, anaemia unresponsive to oral iron treatment should prompt diagnosis for gastrointestinal diseases most common in the paediatric population. Specialised investigations should target the suspected clinical entity, enabling its diagnosis. A correct diagnosis allows for optimal treatment of the underlying disease and, as a result, resolution of the pathology triggering anaemia. However, it takes a long time to regain normal intestinal mucosal function, therefore it is often necessary to additionally include intravenous iron infusions and, in selected cases, packed red blood cell transfusions to rapidly normalise red cell system parameters.

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Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

Chronic anaemia in children as a manifestation of gastrointestinal disorders

Wronecka¹,

Pac-Kożuchowska²,

Mroczkowska-Juchkiewicz³

et al. 2022

Pediatr Med Rodz

View full text Add to dashboard Cite

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Development and Validation of a Multivariable Prediction Model to Identify Acute Exacerbation of COPD and Its Severity for COPD Management in China (DETECT Study): A Multicenter, Observational, Cross-Sectional Study

Yin¹,

Xu²,

Cai³

et al. 2022

COPD

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There is an unmet clinical need for an accurate and objective diagnostic tool for early detection of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). DETECT (NCT03556475) was a multicenter, observational, cross-sectional study aiming to develop and validate multivariable prediction models for AECOPD occurrence and severity in patients with chronic obstructive pulmonary disease (COPD) in China. Patients and Methods: Patients aged ≥40 years with moderate/severe COPD, AECOPD, or no COPD were consecutively enrolled between April 22, 2020, and January 18, 2021, across seven study sites in China. Multivariable prediction models were constructed to identify AECOPD occurrence (primary outcome) and AECOPD severity (secondary outcome). Candidate variables were selected using a stepwise procedure, and the bootstrap method was used for internal model validation. Results: Among 299 patients enrolled, 246 were included in the final analysis, of whom 30.1%, 40.7%, and 29.3% had COPD, AECOPD, or no COPD, respectively. Mean age was 64.1 years. Variables significantly associated with AECOPD occurrence (P<0.05) and severity (P<0.05) in the final models included COPD disease-related characteristics, as well as signs and symptoms. Based on cutoff values of 0.374 and 0.405 for primary and secondary models, respectively, the performance of the primary model constructed to identify AECOPD occurrence (AUC: 0.86; sensitivity: 0.84; specificity: 0.77), and of the secondary model for AECOPD severity (AUC: 0.81; sensitivity: 0.90; specificity: 0.73) indicated high diagnostic accuracy and clinical applicability. Conclusion: By leveraging easy-to-collect patient and disease data, we developed identification tools that can be used for timely detection of AECOPD and its severity. These tools may help physicians diagnose AECOPD in a timely manner, before further disease progression and possible hospitalizations.

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Autoimmune Hemolytic Anemia Induced by Adalimumab

Cited by 2 publications

References 3 publications

Chronic anaemia in children as a manifestation of gastrointestinal disorders

Chronic anaemia in children as a manifestation of gastrointestinal disorders

Development and Validation of a Multivariable Prediction Model to Identify Acute Exacerbation of COPD and Its Severity for COPD Management in China (DETECT Study): A Multicenter, Observational, Cross-Sectional Study

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