Autoimmune hepatitis and pregnancy: considerations for the clinician

Chung, Yooyun; Rahim, Mussarat N.; Heneghan, Michael A.

doi:10.1080/1744666x.2022.2044307

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…Polyspecific Tregs were also used in a clinical trials for AIH (NCT02704338) [ 265 ], Pemphigus Vulgaris NCT03239470, and Lupus Erythematosus NCT02428309 proving safety. However, polyspecific Treg transfer was not very effective in AIH mouse models [ 201 , 203 ].…”

Section: Introductionmentioning

confidence: 99%

Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?

Hardtke-Wolenski,

Landwehr-Kenzel

2024

Mol Cell Pediatr

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Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation route, Tregs can be subdivided into thymically derived Tregs (tTregs) and peripherally induced Tregs (pTregs), which originate from conventional T cells after extrathymic differentiation at peripheral sites. Although the regulatory attributes of tTregs and pTregs partially overlap, their modes of action, protein expression profiles, and functional stability exhibit specific characteristics unique to each subset. Over the last few years, our knowledge of Treg differentiation, maturation, plasticity, and correlations between their phenotypes and functions has increased. Genetic and functional studies in patients with numeric and functional Treg deficiencies have contributed to our mechanistic understanding of immune dysregulation and autoimmune pathologies. This review provides an overview of our current knowledge of Treg biology, discusses monogenetic Treg pathologies and explores the role of Tregs in various other autoimmune disorders. Additionally, we discuss novel approaches that explore Tregs as targets or agents of innovative treatment options.

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Section: Introductionmentioning

confidence: 99%