Autoimmune Hepatitis as a Late Complication of Liver Transplantation

Hernández, Héctor M.; Kovarik, Paula; Whitington, Peter F.; Alonso, Estella M.

doi:10.1097/00005176-200102000-00007

Cited by 110 publications

(91 citation statements)

References 9 publications

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“…However, in univariate analysis there was not a significant difference in the development of d-AIH and primary immunosuppressant (Table 3, p = 0.40). Previous studies have shown variability in the type of primary immunosuppression and the development of d-AIH (3)(4)(5)(6)(7)(8). One of the weaknesses of a retrospective study such as ours is that while it may demonstrate associations, it does not lend itself well toward evaluating the role that one medication versus another may play in the development of d-AIH.…”

Section: Discussionmentioning

confidence: 76%

“…followed by maintenance with either MMF or AzA (3)(4)(5)(6)(7)9,11 Awareness that successful treatment of d-AIH is possible with steroids plus AzA or MMF has led to excellent graft and patient survival. Once therapy for d-AIH was started, LFTs decreased rapidly in all of our patients, and remained significantly reduced at 3 months follow-up.…”

Section: Venick Et Almentioning

confidence: 99%

“…The diagnostic criteria for d-AIH are shown in Figure 1. This disorder affects between 2.1% and 5.2% of pediatric LT patients (3)(4)(5)(6)(7)(8)(9)(10)(11)(12), and between 0.4% and 3.4% of adult recipients (13)(14)(15)(16). The specific long-term treatment and outcome of d-AIH are not well established (4,15).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rejection and Steroid Dependence: Unique Risk Factors in the Development of Pediatric Posttransplant De Novo Autoimmune Hepatitis

Venick¹,

McDiarmid

Farmer³

et al. 2007

American Journal of Transplantation

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Section: Discussionmentioning

confidence: 76%

Section: Venick Et Almentioning

confidence: 99%

See 1 more Smart Citation

Rejection and Steroid Dependence: Unique Risk Factors in the Development of Pediatric Posttransplant De Novo Autoimmune Hepatitis

Venick¹,

McDiarmid

Farmer³

et al. 2007

American Journal of Transplantation

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“…9 Cyclosporin has been implicated in the development of autoimmune hepatitis, and the median interval after liver transplantation was 4 years. The onset in this case was earlier than that in autoimmune hepatitis developing after liver transplantation.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune hepatitis following allogeneic PBSCT from an HLA-matched sibling

Ogose

Watanabe

Suzuya

et al. 2003

Bone Marrow Transplant

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Summary:A 7-year-old boy with acute lymphoblastic leukemia (ALL) in second remission received an allogeneic PBSCT from his HLA-matched sister. Acute grade II graftversus-host disease (GVHD) resolved with corticosteroids. Chronic GVHD in the skin and oral mucosa at around day 60 responded to corticosteroids and cyclosporin A. At 6 months after the transplant, he developed hepatic dysfunction with elevated serum transaminases and gamma-globulin. Liver biopsy revealed chronic inflammation with lymphocytes and plasma cells in portal areas without destruction of bile ducts, suggesting autoimmune hepatitis. While rare, autoimmune hepatitis should be considered a potential long-term complication in patients with hepatic dysfunction in the late post-transplant phase.

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“…Patients without AIH before transplantation can develop autoantibodies either as a complication of otherwise typical rejection 11,12,29 or in association with new-onset AIH. [30][31][32][33][34][35][36] "Non-organ-specific" autoantibodies have been detected in up to 71% of patients after liver transplantation, 37 emphasizing the need for clinicopathological correlation.…”

Section: Practical Problems and Approach To Biopsy Interpretationmentioning

confidence: 99%

Liver biopsy interpretation for causes of late liver allograft dysfunction

2006

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Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late-onset acute and chronic rejection, recurrent and new-onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented. (HEPATOLOGY 2006;44:489-501.)

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Autoimmune Hepatitis as a Late Complication of Liver Transplantation

Cited by 110 publications

References 9 publications

Rejection and Steroid Dependence: Unique Risk Factors in the Development of Pediatric Posttransplant De Novo Autoimmune Hepatitis

Rejection and Steroid Dependence: Unique Risk Factors in the Development of Pediatric Posttransplant De Novo Autoimmune Hepatitis

Autoimmune hepatitis following allogeneic PBSCT from an HLA-matched sibling

Liver biopsy interpretation for causes of late liver allograft dysfunction

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