Autoimmune Hepatitis Overlap with Primary Biliary Cirrhosis in an HIV Infected Patient

Mathur, Jagrati; Lhewa, Dekey; Sheikh, Muhammad Y.

doi:10.14309/00000434-201610001-02687

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…About three dozen cases of AIH have been described in HIV-positive patients with no prior history of abnormal liver enzymes, who developed transaminase abnormalities months to years after starting ART [2][3][4][5]. These cases are mainly of AIH, with only two overlap syndromes with primary biliary cholangitis (PBC) and AIH being reported in the literature [6,7]. The mechanism for this increasingly described entity of immune reconstitution syndrome is not fully understood, but probably involves the rapid increase in CD4+ lymphocyte number after starting ART.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Liver Disease in Human Immunodeficiency Virus-Infected Patients: 3 Case Series

Rafael

Ferreira

Manso

et al. 2022

GE Port J Gastroenterol

View full text Add to dashboard Cite

We present 3 cases of autoimmune liver disease in human immunodeficiency virus (HIV)-infected patients and describe the different diagnostic and therapeutic approaches used in each case. The first patient was diagnosed with primary biliary cholangitis (PBC) with features of autoimmune hepatitis (AIH), requiring second-line therapy due to incomplete response to ursodeoxycholic acid. The second patient was diagnosed with AIH with features of PBC and had the particular challenges of presenting with advanced liver fibrosis and having a past history of disseminated cytomegalovirus infection. The last case concerns an AIH with acute liver injury, successfully treated with corticosteroids and azathioprine. Recently, the number of patients on antiretroviral therapy (ART) for HIV disease has increased significantly. Therefore, more patients with this chronic infection have been diagnosed with autoimmune diseases, leading to concerns regarding immunosuppressive therapies in this population. With these cases, we alert for these increasingly incident diseases and support the safety of immunosuppressive therapies, provided that HIV is suppressed with ART.

show abstract