Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

Perricone, Carlo; Colafrancesco, Serena; Mazor, Roei David; Soriano, Alessandra; Agmon‐Levin, Nancy; Shoenfeld, Yehuda

doi:10.1016/j.jaut.2013.10.004

Cited by 215 publications

(171 citation statements)

References 194 publications

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“…The term "ASIA: Autoimmune/Inflammatory Syndrome Induced by Adjuvants" was coined in 2011 to describe the spectrum of immune-mediated diseases as the result of adjuvants such as chronic silicone exposure (10).…”

Section: Discussionmentioning

confidence: 99%

Dyspnea Associated with Silicone Breast Implant Rupture

Rider¹,

Kaya²,

Gutiérrez³

2015

Eurasian J Pulmonol

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We present a case of a 48-year-old woman with a significant history of atopy. She presented with a 1-month history of dyspnea on exertion. Pulmonary function testing was normal, with no obstruction or reversibility post-bronchodilation. Bilateral breast implant rupture was detected on further investigation for a left upper lobe nodule, and the patient underwent bilateral implant removal. There was an improvement in her respiratory symptoms. Systemic symptoms, labeled as "Autoimmune/Inflammatory Syndrome Induced by Adjuvants," are known to be associated with breast implants, with 14% of women in a cohort developing autoimmune disease secondary to their implants. An improvement in symptoms has been demonstrated following breast implant removal.

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Section: Discussionmentioning

confidence: 99%

Dyspnea Associated with Silicone Breast Implant Rupture

Rider¹,

Kaya²,

Gutiérrez³

2015

Eurasian J Pulmonol

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“…However, our patient was not a known genetic predisposition. Although there were defined minor and major criteria for ASIA, the most prominent feature being emphasized was the development of the autoimmunity/autoimmune disease after exposure to the adjuvant (10). Therefore, this presented case of Sjögren's syndrome that developed after silicone breast implantation was evaluated as an example of ASIA Syndrome.…”

Section: Discussionmentioning

confidence: 99%

Sjögren’s syndrome after silicone breast implantation

et al. 2015

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Sjögren's syndrome, an autoimmune disease characterized by lymphocytic infiltration of the lacrimal and salivary glands, leads to dryness of the mouth and eyes. Herein, we present a case of Sjögren's syndrome that developed after silicone breast implantation. A cause-effect relationship between breast implantation and Sjögren's syndrome has not been established. However, the possibility of such an association should be considered when a patient with silicone implants is admitted to the hospital for treatment of Sjögren's syndrome.

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“…The adjuvant is any substance used to enhance a specific immune response [2]. Several effects of adjuvants on the immune system have been suggested: they can deliver antigens to the immune system; activate innate immune cells through Toll-like receptors (TLR), NOD-like receptors, helicases and C-type lectin receptors; promote the attraction of dendritic cells; increase the uptake of the antigen by antigen-presenting cells (APCs); promote the secretion of cytokines with secondary activation of APCs or activate the inflammasome [3]. A number of evidences have associated these substances with the development of autoimmune phenomena.…”

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confidence: 99%