Autoimmune Liver Diseases

Bylund, David J.; McHutchison, John G.

doi:10.1016/s0272-2712(18)30207-5

Cited by 19 publications

(12 citation statements)

References 40 publications

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“…This is particularly interesting because AMA are very specific for PBC. AMA in patients with PBC recognize the mitochondrial subunits of the 2-oxo acid dehydrogenase complex located in the inner mitochondrial membrane of eukaryotic cells (37). The dominant antigens are the 74-kDa PDC-E2, the 56-kDa E3BP, the 52-kDa BCO-ADC-E2, and the 48-kDa OGDC-E2.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies in Human Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation

Quaranta

Shulman

Ahmed

et al. 1999

Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Autoantibodies in Human Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation

Quaranta

Shulman

Ahmed

et al. 1999

Clinical Immunology

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“…If a rat kidney tissue is used, a faint staining of the mesangial area of glomeruli and of the brush border of proximal renal tubular cells is also present. Also Hep-2 cells can be used as substrate and, if present, SMA are evidenced in "cable like" cytoplasmic staining [146]. Although SMA are present in different liver diseases, in autoimmune liver diseases are directed mostly against Factin, present in hepatocytes as a part of the cytoskeleton in close proximity with the plasma membrane.…”

Section: Autoantibodiesmentioning

confidence: 99%

“…SMA. With F-actin specificity can be detected using fibroblasts cultured in presence of colchicine or on Hep-2 cells as mentioned above [146]. Interestingly, adults with actin-positive autoantibodies are younger, more commonly DR3 positive and have a more severe disease than other patients with ANA and without actin reactivity [148].…”

Section: Autoantibodiesmentioning

confidence: 99%

Autoimmune Hepatitis: A Childhood Disease

Maggiore¹,

Sciveres²

2005

CPR

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Autoimmune hepatitis is a severe and unresolving inflammatory disease of the liver of unknown etiology carrying high morbidity and mortality. All ages and genders are concerned with a peak of incidence in girls in prepubertal age, even if the disease has been diagnosed as early as 6 months. Autoimmune hepatitis may be classified in two major subgroups on a presence of a specific set of autoantibodies: anti-smooth muscle mostly with anti-actin specificity and/or by antinuclear antibody in type 1 and anti-liver-kidney microsome and/or the anti-liver cytosol in type 2. The histological hallmark is "interface hepatitis", with a mononuclear cell infiltrate in the portal tracts, variable degrees of necrosis, and progressive fibrosis. The disease follows a chronic but fluctuating course usually progressing to cirrhosis and liver failure. The most frequent type onset is similar to that of an acute viral hepatitis with acute liver failure in some patients; about a third of patients have an insidious onset with progressive fatigue and jaundice while 10-15% are asymptomatic and are accidentally discovered by the finding of hepatomegaly and/or an increase of serum aminotransferase activity. Corticosteroids alone or in conjunction with azathioprine are the treatment of choice inducing remission in over 90% of patients. An alternative therapeutic strategy is cyclosporine. Withdrawal of immunosuppression is associated with high risk of relapse. Liver transplantation manages patients with decompensated liver disease unresponsive to "rescue" medical treatment.

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“…87 Similar to PBC, treatment largely revolves around the use of bile-solubilizing UDCA because other immunosuppressive agents have not shown consistent efficacy. 10,87,143,144 As in the setting of PBC, it is accepted that cholangiopathic sarcoidosis can histologically and clinically mimic PSC. 44,50,[145][146][147][148] Furthermore, the presence of other coexisting autoimmune syndromes must be considered which may affect the lung of a PSC patient.…”

Section: Pulmonary Manifestations Of Pscmentioning

confidence: 99%

Pulmonary Manifestations of Primary Autoimmune Hepatobiliary Disease

Allan¹,

Powers²,

Morris³

2005

Clinical Pulmonary Medicine

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The autoimmune hepatobiliary diseases are associated with a variety of pulmonary manifestations. There is increasing evidence of autoimmune pathophysiology occurring within the hepatopulmonary axis that may lead to clinically evident disease. Primary biliary cirrhosis (PBC) figures prominently among the primary autoimmune hepatobiliary processes with pulmonary involvement. PBC has been associated with subclinical alveolitis, sarcoidosis, bronchiolitis obliterans with organizing pneumonia, and lymphoid interstitial pneumonia, among others. Clinical associations have also been made between primary sclerosing cholangitis (PSC) and sarcoidosis, pulmonary fibrosis, or alveolar hemorrhage. Last, an evaluation of the current diagnostic criteria of autoimmune hepatitis has led to a reconsideration of its association with pulmonary fibrosis. Through a heightened clinical suspicion for these potential relationships, an improvement can be made in our comprehension of these autoimmune hepatobiliary processes and their impact on pulmonary physiology.

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Autoimmune Liver Diseases

Cited by 19 publications

References 40 publications

Autoantibodies in Human Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation

Autoantibodies in Human Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation

Autoimmune Hepatitis: A Childhood Disease

Pulmonary Manifestations of Primary Autoimmune Hepatobiliary Disease

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