Autoimmune Manifestations of Kikuchi Disease

Sopeña, B.; Rivera, Alberto; Vázquez-Triñanes, C.; Fluiters, Enrique; González-Carreró, Joaquín; Pozo, M. Del; Freire, Mayka; Martínez-Vázquez, C.

doi:10.1016/j.semarthrit.2011.11.001

Cited by 71 publications

(82 citation statements)

References 35 publications

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“…Kikuchi's disease has been mistaken for malignant lymphoma and some initially misdiagnosed patients were treated with chemotherapy [5,9]. It is thus important to be aware of this entity.…”

Section: Discussionmentioning

confidence: 99%

“…The histopathological diagnosis can be elusive and Kikuchi's disease has been mistaken for reactive lymphadenitis as well as NHL [9]. The latter perhaps due to obliteration of sinuses and proliferations of plasmacytoid monocytes and immunoblasts [10].…”

Section: Discussionmentioning

confidence: 99%

“…Fine-needle aspiration biopsy (FNAB) cannot provide the diagnosis, so a whole lymph node should be excised for histopathological examination [9]. The typical indings are coagulative necrosis, foci of various histiocytes, debris, immunoblasts (T-cells) together with large and small lymphocytes [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The typical indings are coagulative necrosis, foci of various histiocytes, debris, immunoblasts (T-cells) together with large and small lymphocytes [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Some recommend non-steroidal anti-in lammatory drugs (NSAID) for symptom relief and in more aggressive cases systemic corticosteroids [5,6,11]. Symptoms most frequently resolve within 6 months [1,9], but has been reported to last up to 37 months [12].…”

Section: Introductionmentioning

confidence: 99%

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Kikuchi’s disease in a young Scandinavian woman

SMS¹

2017

Heighpubs Otolaryngol and Rhinol

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A 21 year-old woman presented with cervical lymphadenopathy and night sweats. Initially, lymphoma was suspected and one of the enlarged lymph nodes was excised in order to make a diagnosis. Histopathological examination revealed Kikuchi's disease, which is usually a benign syndrome with spontaneous resolution. The disease is very rare, particularly in Caucasian populations. A higher incidence is seen in patients of Asian descent.The patient had persistent swelling of cervical lymph nodes over several months and further lymph nodes were removed as malignant transformation was suspected. However examinations showed only Kikuchi's disease. There was given no specifi c treatment. Follow-up appointments were performed biannually and the patient is currently awaiting removal of yet another swollen lymph node on suspicion of relapse of her Kikuchi's disease.

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“…Kikuchi's disease has been mistaken for malignant lymphoma and some initially misdiagnosed patients were treated with chemotherapy [5,9]. It is thus important to be aware of this entity.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The typical indings are coagulative necrosis, foci of various histiocytes, debris, immunoblasts (T-cells) together with large and small lymphocytes [9,10].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kikuchi’s disease in a young Scandinavian woman

SMS¹

2017

Heighpubs Otolaryngol and Rhinol

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Kikuchi Cervical Lymphadenitis in Children

Park

Kim

Ryu

et al. 2020

J of Ultrasound Medicine

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Objectives To investigate ultrasound (US) features of enlarged cervical lymph nodes (LNs) to differentiate between Kikuchi disease (KD) and other common types of infectious lymphadenitis in an East Asian pediatric patient population. Methods A total of 142 pediatric patients with KD and 45 patients with infectious lymphadenitis (suppurative lymphadenitis [n = 29], nontuberculous mycobacterial lymphadenitis [n = 9], and tuberculous lymphadenitis [n = 7]) were included. The clinical characteristics, laboratory results, and US features of LNs were reviewed. The area under the curve (AUC) from a receiver operating characteristic curve analysis was used as a diagnostic accuracy measure. Results A multiple clustered adjacent pattern, bilaterality, an even size, posterior neck involvement, no enlargement, an elongated‐to‐ovoid shape, homogeneous hypoechogenicity, a well‐defined margin, presence of an echogenic fatty hilum, no intranodal gross necrosis, increased perinodal fat echogenicity, and no increased echogenicity of the adjacent sternocleidomastoid muscle were significant US features of the affected LNs to discriminate KD from infectious lymphadenitis (P < .05). Homogeneous hypoechogenicity in KD showed the highest AUC (0.930) as a single variable (95% confidence interval, 0.88–0.96). The AUCs were increased in 3 combination models with 2 US features: homogeneous echogenicity and 1 of 3 other US features (increased perinodal fat echogenicity, 0.935; number of affected LNs, 0.947; and LN shape, 0.949). Conclusions Homogeneous hypoechogenicity of LNs was a significant US feature with the highest diagnostic accuracy in differentiating KD from common infectious lymphadenitis on a univariate analysis. In the combination model, US features of an elongated‐to‐ovoid shape and homogeneous hypoechogenicity showed the highest diagnostic accuracy.

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Cutaneous Hematopathology

2014

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Autoimmune Manifestations of Kikuchi Disease

Cited by 71 publications

References 35 publications

Kikuchi’s disease in a young Scandinavian woman

Kikuchi’s disease in a young Scandinavian woman

Kikuchi Cervical Lymphadenitis in Children

Cutaneous Hematopathology

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