Autoimmune pancreatitis as a systemic, protracted and potentially fatal disease

Pasierbek-Kohutek, Aneta; Gutkowski, Krzysztof; Barczyk, Anna; Hartleb, Marek; Paleń, Piotr

doi:10.5114/pg.2013.34187

Cited by 2 publications

(2 citation statements)

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“…Focal changes of pancreatic parenchyma are often documented on diagnostic imaging. In view of the clinical manifestation and changes documented on imaging, pancreatic cancer followed by inflammatory masses associated with CP should be considered on differential diagnosis of AIP [ 2 , 4 , 9 , 12 , 17 , 18 ]. Diagnostic imaging revealed pancreatic head masses in three of our patients with AIP.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune markers in children with chronic pancreatitis

Oracz¹,

Cukrowská²,

Kierkuś³

et al. 2014

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IntroductionIn the last decade we can observe a gradual increase in the incidence of autoimmune diseases. The aetiology of chronic pancreatitis (CP) in children is varied and includes gene mutations, anatomic anomalies and others. The reported paediatric experience with chronic CP is scarce and little is known about the role of autoimmune pancreatitis (AIP).AimTo assess the frequency of autoimmune markers in children with CP.Material and methodsOne hundred and twenty-nine children hospitalised between 2005 and 2012 at the Department of Gastroenterology, The Children's Memorial Health Institute, were examined for the presence of AIP; the level of IgG4 was determined, and tests for anti-tissue antibodies (ANA, ASMA, AMA, ANCA, AHA) were conducted. Clinical data were recorded and analysed.ResultsAnti-tissue antibodies were detected in 75/129 children (58%), and 24/68 patients (35.3%) showed an increased IgG4 level. Based on the International Association of Pancreatology criteria, a suspicion of AIP was raised in 6 patients (4.6%). We found gene mutations predisposing to CP in 32/75 (42.6%) patients with autoimmune markers. In 16/75 children (21.3%), anatomic anomalies were found. There was no difference in the severity of the disease and clinical course between children with evidence of autoimmune process and patients without autoimmune markers (p = NS).ConclusionsIn children with CP, similarly to adults, there is a high frequency of biochemical markers of autoimmunity. It is worth remembering that AIP can occur in children.

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Section: Discussionmentioning

confidence: 99%

Autoimmune markers in children with chronic pancreatitis

Oracz¹,

Cukrowská²,

Kierkuś³

et al. 2014

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“…In every person suffering from autoimmune disease, particularly of the endocrine glands, the possibility of APS occurrence needs to be considered in the differential diagnosis, testing for the possible coexistence of diabetes type 1, thyroid dysfunction, Addison’s disease, celiac disease, and autoimmune hepatitis, also smooth muscle, and antigens LMC-1 and SLA is recommended [ 12 , 13 ].…”

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confidence: 99%

Autoimmune pancreatitis as a component of autoimmune polyglandular syndrome

Piotrowicz

Stępień

Klufczyńska

2017

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Autoimmune pancreatitis as a systemic, protracted and potentially fatal disease

Cited by 2 publications

References 20 publications

Autoimmune markers in children with chronic pancreatitis

Autoimmune markers in children with chronic pancreatitis

Autoimmune pancreatitis as a component of autoimmune polyglandular syndrome

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