Autoimmune pancreatitis characterized by predominant CD8+ T lymphocyte infiltration

Abstract

severe jaundice and sustained abdominal distension. Prednisone 30 mg/d was administered orally as an AIP was suspected. One and a half months later, the symptoms of the patient disappeared, and globulin, aminotransferase and bilirubin levels decreased significantly. Over a 9-mo follow-up period, the dose of prednisone was gradually decreased to 10 mg/d and the patient remained in good condition. We further demonstrated dominant CD3+/CD8+ populations, CD20+ cells and a few CD4+ cells in the pancreatic parenchyma, duodenum and gallbladder wall by immunohistochemical assay. This AIP case presented with significant CD8+ T lymphocyte infiltration in the pancreas and extra-pancreatic lesions, indicating that this cell population may be more important in mediating AIP pathogenesis than previously known and that AIP might be a poorly defined autoimmune disease with heterogeneous pathogenesis.

Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis

“…6B-D) and immunohistological findings obtained by Suda et al, suggesting that an irAE due to an ICI had occurred (2,8). Infiltrations of both CD4-and CD8positive T cells in the pancreas have also been reported in type 1 AIP cases (19,20). Whether or not this phenomenon is involved in the pathogenesis of type 1 AIP and whether this phenomenon is also found in type 2 AIP are unclear at present.…”