Autoimmune pernicious anaemia as a cause of collapse, heart failure and marked panyctopaenia in a young patient

Carey, Justin; Hack, Ebru

doi:10.1136/bcr.01.2012.5576

Cited by 4 publications

(2 citation statements)

References 12 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, PA and IDA may concurrently cause dysmorphic anemia with normal MCV and anisocytosis [37]. Symptoms of anemia, of all kinds, are predominantly fatigue, dyspnea, peripheral edema, and, in some cases, heart failure [10,38,39]. Unfortunately, anemic patients (without gastrointestinal bleeding) often are not referred to gastroenterologists, and anemia is treated without further investigation, causing a great diagnostic delay [10,11,35].…”

Section: Epidemiological Pathogenetic Clinical and Diagnostic Issues ...mentioning

confidence: 99%

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Vavallo,

Cingolani,

Cozza

et al. 2024

IJMS

View full text Add to dashboard Cite

Autoimmune atrophic gastritis is an immune-mediated disease resulting in autoimmune destruction of the specialized acid-producing gastric parietal cells. As a consequence, in autoimmune atrophic gastritis, gastric acid secretion is irreversibly impaired, and the resulting hypochlorhydria leads to the main clinical manifestations and is linked, directly or indirectly, to the long-term neoplastic complications of this disease. In the last few years, autoimmune atrophic gastritis has gained growing interest leading to the acquisition of new knowledge on different aspects of this disorder. Although reliable serological biomarkers are available and gastrointestinal endoscopy techniques have substantially evolved, the diagnosis of autoimmune atrophic gastritis is still affected by a considerable delay and relies on histopathological assessment of gastric biopsies. One of the reasons for the diagnostic delay is that the clinical presentations of autoimmune atrophic gastritis giving rise to clinical suspicion are very different, ranging from hematological to neurological–psychiatric up to gastrointestinal and less commonly to gynecological–obstetric symptoms or signs. Therefore, patients with autoimmune atrophic gastritis often seek advice from physicians of other medical specialties than gastroenterologists, thus underlining the need for increased awareness of this disease in a broad medical and scientific community.

show abstract

Section: Epidemiological Pathogenetic Clinical and Diagnostic Issues ...mentioning

confidence: 99%

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Vavallo,

Cingolani,

Cozza

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Patients can develop complications of B12 deficiency if not diagnosed and treated early 13. There have been case reports of heart failure due to severe anaemia 9. It is uncertain how common haematological and neurological complications are in pernicious anaemia.…”

Section: Why Does It Matter?mentioning

confidence: 99%

Pernicious anaemia

Mohamed

Thio

Thomas

et al. 2020

BMJ

View full text Add to dashboard Cite

A woman with macrocytic anaemia and confusion

Sugrue

Egan

O’Regan

2014

BMJ

View full text Add to dashboard Cite

An 82 year old woman with a history of type 2 diabetes presented with unsteady gait and confusion of two months' duration. Her diabetes was controlled by metformin (500 mg, three times a day) and she had no other comorbidities. She was a non-smoker and did not drink alcohol. Dietary history showed an adequate intake of meat, vegetables, and calories.On examination, her vital signs were stable. She was disorientated in time but not in person or place. Cranial nerve examination was normal but examination of the peripheral nervous system showed ataxia and impaired proprioception of the lower limbs bilaterally. The rest of her examination was normal. Her score on the mini-mental state examination at presentation was 18 out of 30.Correspondence to: A Sugrue

show abstract

Autoimmune pernicious anaemia as a cause of collapse, heart failure and marked panyctopaenia in a young patient

Cited by 4 publications

References 12 publications

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Pernicious anaemia

A woman with macrocytic anaemia and confusion

Contact Info

Product

Resources

About