Autoimmune potential of perchloroethylene: Role of lipid-derived aldehydes

Wang, Gangduo; Wang, Jianling; Ansari, Ghulam; Khan, M. Firoze

doi:10.1016/j.taap.2017.08.009

Cited by 9 publications

(3 citation statements)

References 61 publications

(162 reference statements)

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“…Aldehydes found in components of e-cigs are also linked to a higher risk of autoimmune reactions 115 . A murine model demonstrated an increase in autoimmune markers in mice exposed to perchloroethylene in the water at 12, 18 and 24 weeks, including levels of serum ANA (anti-nuclear antibodies), dsDNA (double-stranded DNA) and Scl-70 (scleroderma) antibodies.…”

Section: Oral Lesionsmentioning

confidence: 99%

Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity

Ebersole¹,

Samburova²,

Son³

et al. 2020

Tob. Induc. Dis.

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Use of electronic nicotine delivery systems (ENDS), such as electronic cigarettes (e-cigs), is increasing across the US population and is particularly troubling due to their adoption by adolescents, teens, and young adults. The industry's marketing approach for these instruments of addiction has been to promote them as a safer alternative to tobacco, a behavioral choice supporting smoking cessation, and as the 'cool' appearance of vaping with flavored products (e.g. tutti frutti, bubble gum, and buttered popcorn etc.). Thus, there is a clear need to better document the health outcomes of e-cig use in the oral cavity of the addicted chronic user. There appears to be an array of environmental toxins in the vapors, including reactive aldehydes and carbonyls resulting from the heating elements action on fluid components, as well as from the composition of chemical flavoring agents. The chemistry of these systems shows that the released vapors from the e-cigs frequently contain levels of environmental toxins that considerably exceed federal occupational exposure limits. Additionally, the toxicants in the vapors appear to be retained in the host fluids/tissues at levels often approximating 90% of the levels in the e-cig vapors. These water-soluble reactive toxins can challenge the oral cavity constituents, potentially contributing to alterations in the autochthonous microbiome and host cells critical for maintaining oral homeostasis. This review updates the existing chemistry/environmental aspects of e-cigs, as well as providing an overview of the somewhat limited data on potential oral health effects that could occur across the lifetime of daily e-cig users.

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Section: Oral Lesionsmentioning

confidence: 99%

Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity

Ebersole¹,

Samburova²,

Son³

et al. 2020

Tob. Induc. Dis.

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show abstract

“…The same study described how patients exposed to solvents showed more Scl70 antibodies than controls. Even though the biological mechanisms that trigger SSc in a solvent-exposure scenario remain unclear, several studies have suggested its biological plausibility [8,43,44].…”

Section: Solventsmentioning

confidence: 99%

Should systemic sclerosis be recognised as an occupational disease in Switzerland?

et al. 2020

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Systemic sclerosis is a rare autoimmune disease characterised by a multifactorial aetiology involving a gene-environment interaction. Despite the growing epidemiological arguments for odds ratio (OR) data showing an association with occupational exposure, systemic sclerosis is not currently included in the list of recognised occupational diseases in Switzerland, unlike other northern European countries. Future recognition will be conditional on the demonstration of a strong association between the disease and occupational exposure in the scientific literature. The present article's main goal is to present five cases of systemic sclerosis investigated for possible occupational aetiologies during occupational pathology consultations at the Institute for Work and Health, in Lausanne. The occupational aetiologies of these cases are discussed against the background of a literature review of publications from the past 20 years in order to determine whether recognition as an occupational disease is possible within Switzerland's legal framework. Epidemiological studies of systemic sclerosis have identified strong associations with occupational factors such as exposure to silica and solvents, with ORs >2, and weaker associations with epoxy resins and welding fumes. Other occupational exposures are also known to induce systemic sclerosis-like diseases, such as vinyl chloride disease and toxic oil syndrome. All five patients had been exposed to either silica, solvents, or both. Given their exposure and the data in the literature, four patients had their cases declared to their accident insurance companies and two of them were recognised as suffering from an occupational disease by the Swiss National Accident Insurance Fund. Our literature review enabled us to design a short questionnaire to help general practitioners and rheumatologists to identify those patients with systemic sclerosis who are likely to have their illness recognised as an occupational disease.

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“…Environmental factors have gained much attention in recent years for their role in triggering autoimmunity, with increasing evidence of their influence being apparent from epidemiological and animal studies (39). These factors, including cigarette smoking, crystalline silica, and exposures to trichloroethylene (TCE), perchloroethylene, mercury, pesticides, and pristane are implicated in increasing the risk for ADs (4,40–42). Such factors are considered serious threats in the etiology and progression of ADs such as SLE, rheumatic arthritis, systemic sclerosis, and autoimmune hepatitis.…”

Section: Environmental Agents Oxidative Stress and Autoimmunitymentioning

confidence: 99%

Environmental agents, oxidative stress and autoimmunity

Khan

Wang

2018

Current Opinion in Toxicology

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Oxidative stress (OS) plays an important role in the pathogenesis of a variety of autoimmune diseases (ADs) and many environmental agents participate in this process. Environmental agents, including trichloroethylene (TCE), silica, pristane, mercury, and smoke, are known to induce an autoimmune response, potentially through OS-mediated mechanisms. Here, we focus on unraveling the targets and signaling pathways that have been mechanistically linked with OS, as a result of exposure to these and numerous other environmental agents, and their impact on the immune system in triggering ADs. Antioxidants and molecular targets impeding autoimmunity by targeting specific signaling pathways are also reviewed. The review not only provides an overview of the current knowledge and evidence showing strong associations between environmental exposures, OS, and ADs, but also plausible mechanisms by which OS causes autoimmunity/ADs. We also discuss areas that require additional approaches, such as unraveling specific events/mechanisms leading to such devastating diseases and measures to prevent or attenuate such diseases.

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Autoimmune potential of perchloroethylene: Role of lipid-derived aldehydes

Cited by 9 publications

References 61 publications

Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity

Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity

Should systemic sclerosis be recognised as an occupational disease in Switzerland?

Environmental agents, oxidative stress and autoimmunity

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