Autoimmune Retinopathy in Benign Thymoma after Good Syndrome-associated Cytomegalovirus Retinitis

Wan, Chee Kwang; Teoh, Stephen C.

doi:10.3109/09273948.2012.730652

Cited by 11 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thymoma and paraneoplastic retinopathy have been reported in sparse case reports in the literature, with the onset of retinopathy largely preceding the diagnosis of the thymoma 17–23. Thymic dysfunction is suggested to trigger autoantibodies targeting retinal antigens, leading to photoreceptor degeneration and progressive loss of visual function.…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of thymoma: dysgeusia, ulcerative colitis, keratoconjunctivitis sicca, autoimmune retinopathy and myasthenia gravis

Sanghi

Bremner

2022

BMJ Case Rep

View full text Add to dashboard Cite

A 41-year-old female presented with dysgeusia, dry eyes, nyctalopia with progressive visual field constriction (due to autoimmune retinopathy) and gastrointestinal symptoms (due to ulcerative colitis). She was subsequently admitted to intensive care with a myasthenic crisis, and CT of the thorax demonstrated a thymoma.Following thymectomy and adjuvant radiotherapy, she has remained in complete remission from her ulcerative colitis and myasthenia gravis, her retinopathy has stabilised and there has been no thymoma recurrence over a 10-year postoperative period. There was a brief relapse of her dysgeusia (causing weight loss) and dry eye symptoms 3 years after her surgery, which resolved 8 months later. While the association of thymomas with paraneoplastic syndromes (PNS) is well established, it is unusual to present with multiple PNS, and some of these have only been documented in sparse case reports to date. Thymectomy played a crucial role in improvement and stabilisation of her PNS.

show abstract

Section: Discussionmentioning

confidence: 99%

An unusual presentation of thymoma: dysgeusia, ulcerative colitis, keratoconjunctivitis sicca, autoimmune retinopathy and myasthenia gravis

Sanghi

Bremner

2022

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…There are further studies concerning patients with thymoma excision, visual loss and Good's syndrome. The aqueous humor or vitreous fluid samples from two patients with thymoma were found to be positive for CMV DNA by PCR analysis, which is clinically consistent with CMV retinitis 6,7 . Similarly, the visual acuity of one case was enhanced and CMV retinitis was controlled after 1 month of intravenous antiviral therapy 6 .…”

Section: Viral Infection In the Pathogenesis Of Thymoma And Related Diseasesmentioning

confidence: 77%

“…The aqueous humor or vitreous fluid samples from two patients with thymoma were found to be positive for CMV DNA by PCR analysis, which is clinically consistent with CMV retinitis. 6 , 7 Similarly, the visual acuity of one case was enhanced and CMV retinitis was controlled after 1 month of intravenous antiviral therapy. 6 According to Huissoon et al, a patient was found to be CMV positive following PCR analysis of a vitreous fluid biopsy and CMV antigen detection from blood.…”

Section: Viral Infection In the Pathogenesis Of Thymoma And Related Diseasesmentioning

confidence: 87%

Viral infection in thymoma and thymic tumors with autoimmune diseases

Chang

Duan

et al. 2021

Thoracic Cancer

View full text Add to dashboard Cite

A thymoma is a type of thymic tumor which is rarely malignant that is frequently reported in adult patients. A number of thymoma‐related immune disorders are observed including autoimmune diseases, which suggests a strong connection between thymoma development and immunological mechanisms. Characterized by association with humoral and cellular immunodeficiency, thymoma patients are susceptible to opportunistic infections by environmental factors. Recent reports have suggested that viral infection may play a role in the etiological mechanisms of thymoma development associated with dysregulated immunity. In this review, we summarize the case reports and studies related to viral infection, such as CMV, EBV and HSV, that probably play a part in the pathogenesis of thymoma and related diseases. Furthermore, we demonstrate the underlying mechanisms by which viruses may induce the occurrence of thymoma with autoimmune diseases. Lastly, we discuss the potential application of antiviral therapy in the treatment of thymic diseases.

show abstract

Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review

et al. 2020

View full text Add to dashboard Cite

Autoimmune Retinopathy in Benign Thymoma after Good Syndrome-associated Cytomegalovirus Retinitis

Cited by 11 publications

References 14 publications

An unusual presentation of thymoma: dysgeusia, ulcerative colitis, keratoconjunctivitis sicca, autoimmune retinopathy and myasthenia gravis

An unusual presentation of thymoma: dysgeusia, ulcerative colitis, keratoconjunctivitis sicca, autoimmune retinopathy and myasthenia gravis

Viral infection in thymoma and thymic tumors with autoimmune diseases

Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review

Contact Info

Product

Resources

About