Autoimmune syndrome induced by omeprazole

Sivakumar, Keithan; Dalakas, M. C.

doi:10.1016/s0140-6736(94)92008-7

Cited by 20 publications

(15 citation statements)

References 5 publications

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“…As a family, PPIs have been considered to be well tolerated, with minor side‐effects, involving mainly the gastrointestinal tract, the central nervous system and the skin. An autoimmune syndrome with the characteristics of lupus 2 or bullous pemphigoid 3 has been rarely associated with omeprazole.…”

mentioning

confidence: 99%

Possible phototoxicity with subsequent progression to discoid lupus following pantoprazole administration

Correia¹,

Viana²,

Azevedo

et al. 2001

Clinical and Experimental Dermatology

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mentioning

confidence: 99%

Possible phototoxicity with subsequent progression to discoid lupus following pantoprazole administration

Correia¹,

Viana²,

Azevedo

et al. 2001

Clinical and Experimental Dermatology

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“…There was no renal involvement. This druginduced lupus syndrome resolved within 2 months of stopping treatment [16]. Taken together, these observations suggest, at least regarding omeprazole, that druginduced immunoallergic interstitial nephritis is more liable to occur in patients having, overtly or covertly, a deranged immunologic status.…”

Section: Discussionmentioning

confidence: 81%

Immunoallergic Granulomatous Interstitial Nephritis following Treatment with Omeprazole

Montseny

Meyrier

1998

Am J Nephrol

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A 69-year-old male who had a long history of ocular myasthenia was treated with omeprazole for 3 months. Progressive renal insufficiency was discovered fortuitously. There were no clinical or laboratory manifestations of immunoallergy. Renal biopsy revealed severe granulomatous interstitial nephritis, tubular injury and fibrosis. Histology of a liver nodule disclosed hepatic granulomatous involvement. Withdrawal of omeprazole and a short course of corticosteroids were followed by improvement but not normalization of renal function. This is the eighth report of omeprazole-induced interstitial nephritis. In the present case as in 2 others in the literature, the patients had been followed up for an autoimmune disease previously, which suggests that in patients with such a background, patients should be examined regularly for renal functional impairment during treatment with omeprazole.

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“…The role of omeprazole in in ducing urticaria has been documented by rechallenge in a single case report 127]. Recently, lupus erythematosus [28], pemphigoid exacerbation [29], toxic epidermal necrolysis [30] and a reversible toxic bullous reaction [31 ] have been associated with omeprazole. Lupus-like syndrome has also been reported in association with domperidone [32], No such reactions were reported to our system.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Reactions to Alimentary Tract Medications: Results of a Seven-Year Surveillance Program and Review of the Literature

Dermatologia¹

1996

Dermatology

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Background: No systematic review of skin reactions to alimentary tract medications is available in the literature. Objective: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). Methods: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center of GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02–A04, A06, A07 and A09 were used for this analysis. Results: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70% of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. Conclusion: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.

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Autoimmune syndrome induced by omeprazole

Cited by 20 publications

References 5 publications

Possible phototoxicity with subsequent progression to discoid lupus following pantoprazole administration

Possible phototoxicity with subsequent progression to discoid lupus following pantoprazole administration

Immunoallergic Granulomatous Interstitial Nephritis following Treatment with Omeprazole

Cutaneous Reactions to Alimentary Tract Medications: Results of a Seven-Year Surveillance Program and Review of the Literature

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