Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics

Lazúrová, Ivica; Jochmanová, Ivana; Benhatchi, Karim; Sotak, Štefan

doi:10.1007/s12026-014-8598-9

Cited by 43 publications

(45 citation statements)

References 62 publications

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“…The close relationship of ATD with rheumatologic disease has led to speculation on possible reasons for the association [30,31]. There are considerable similarities in genetics and a significant overlap in clinical presentation between several CTD and ATD even in the absence of welldefined CTD [16,31].…”

Section: Discussionmentioning

confidence: 99%

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Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

2015

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To investigate how autoimmune thyroiditis (ATD) affects the clinical presentation of established rheumatoid arthritis (RA) with particular reference to fibromyalgia and chronic widespread pain (CWP). A cohort of 204 patients with RA for whom the presence or absence of autoimmune thyroid antibodies was documented was examined for the relationships between thyroid autoantibodies and fibromyalgia or CWP. We identified 29 % who tested positive for antithyroid peroxidase antibodies (TPOAb). The anti-thyroglobulin antibody (TgAb) was found in 24 %. Among the thyroid autoantibody-positive patients, 40 % had a diagnosis of fibromyalgia or CWP versus 17 % for antibody negative patients. Logistic regression analyses (adjusted by age, sex, diabetes and BMI) indicated that TPOAb-positive patients were more likely to have fibromyalgia or CWP, with an odds ratio (OR) of 4.641, 95 % confidence interval (CI) (2.110-10.207) P < .001. Adjusting for spinal degenerative disc disease did not change the association with fibromyalgia, OR 4.458, 95 % CI (1.950-10.191), P < .001. The OR between TgAb and fibromyalgia was not significant (P > .05). Additional logistic regression analyses (adjusted by age, sex and BMI) indicated a significant relationship between TPOAb and fibromyalgia or CWP in patients without diabetes and those without hypothyroidism (OR of 4.873, 95 % CI (1.877-12.653), P = .001 and OR of 4.615 95 % CI (1.810-11.770), P = .001, respectively). There may be a positive association between the ATD antibody TPOAb, and fibromyalgia syndrome and CWP in patients with established RA.

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Section: Discussionmentioning

confidence: 99%

“…There are considerable similarities in genetics and a significant overlap in clinical presentation between several CTD and ATD even in the absence of welldefined CTD [16,31]. There may therefore at least in some ATD patients be a generalized autoimmune process with systemic clinical manifestations.…”

Section: Discussionmentioning

confidence: 99%

Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

2015

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“…It has also been suggested that genetic factors have pleiotropic effects and predispose to a number of different diseases , but the fetal adaption as a consequence of maternal RA might also induce epigenetic changes that increase the accumulation of diseases, e.g., RA, in the offspring .Thus, our study cannot determine the underlying biologic mechanisms, i.e., the role or contribution of genetic factors and factors related to the intrauterine environment. Genetic factors might explain the excess morbidity when it comes to RA in the offspring, and genetic factors showing pleiotropic effects might also explain the occurrence of other diseases such as autoimmune thyroid disease . However, the results might also partly be due to factors related to an impact of maternal RA itself on the fetal environment, e.g., an impact due to disease activity or medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Children Born by Women With Rheumatoid Arthritis and Increased Susceptibility for Chronic Diseases: A Nationwide Cohort Study

Jølving

Nielsen

Kesmodel

et al. 2018

Arthritis Care & Research

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Our results suggest that in utero exposure to maternal RA is associated with an increased risk of thyroid disease and epilepsy in childhood and adolescence, and in particular an increased risk of RA, compared to children born to mothers without RA. These important findings should encourage pediatricians and general practitioners to have an increased awareness of certain chronic diseases in children exposed to RA in utero.

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“…Nowadays, autoimmune diseases are a growing and disturbing health problem, especially as the autoimmune process is activated by genetic and environmental factors that are difficult to identify, and leads to the development of concomitant diseases in other systems. In AITDs, intolerance is caused by the interference with T-cells function and the production of antibodies against the specific cell antigens (Iddah et al, 2013;Pyzik et al, 2015). The autoimmune reaction is possible because of the polymorphisms in major histocompatibility genes (human leukocyte antigen (HLA)), thyroid-specific genes, immunoregulatory genes, and may be sparked by various exogenous (environmental) factors i.e.…”

Section: The Immunopathology Of Autoimmune Thyroid Diseasesmentioning

confidence: 99%

The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases

Tomczyńska

Saluk‐Bijak

2018

Acta Biochim Pol

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Autoimmune thyroid diseases include several distinct clinical entities, mainly Graves' disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body's own tissues, and the production of antibodies against specific cell antigens accompanied by chronic inflammation, all occur in autoimmune thyroid diseases. The autoimmune process is induced by genetic and environmental factors that are difficult to identify and generates the development of concomitant diseases in other systems. Leukocyte activation and overproduction of inflammatory mediators, as well as improper levels of thyroid hormones, play an essential role in the chronic course of these diseases. The development of autoimmune thyroid diseases results from the impairment of the regulatory and suppressor functions of T-cells or NK cells and activation of B cells, or from the changes in the number of those cells. Many reports have shown the significant role of platelet-leukocyte interaction in inflammation. Autoantibodies react with target antigens in different kinds of cells, including blood platelets, and autoimmune processes can modulate the mutual cooperation of blood platelets and lymphocytes. The activity of blood platelets and lymphocytes is reciprocally regulated. It has been suggested that blood platelets can influence lymphocyte function by direct contact with receptors, and indirectly via soluble mediators. The interactions of platelet-immune cells (neutrophils, monocytes, lymphocyte and dendritic cells) can have a potent enhancing effect on immune cells functions.

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Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics

Cited by 43 publications

References 62 publications

Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

Children Born by Women With Rheumatoid Arthritis and Increased Susceptibility for Chronic Diseases: A Nationwide Cohort Study

The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases

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