Autoimmune thyroid disease in <scp>C</scp>olombian patients with systemic lupus erythematosus

Franco, Juan Sebastian; Amaya-Amaya, Jenny; Molano-González, Nicolas; Caro-Moreno, Julián; Rodríguez-Jiménez, Mónica; Acosta-Ampudia, Yeny; Mantilla, Rubén D.; Rojas-Villarraga, Adriana; Anaya, Juan Manuel

doi:10.1111/cen.12662

Cited by 47 publications

(57 citation statements)

References 32 publications

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“…OR = odds ratio, with 95% confidence interval in parentheses; TPO = thyroid peroxidase; Tg = thyroglobulin. Regarding SLE, a Colombian study 5 found that the prevalence of hypothyroidism was 12% in their cohort, thus corroborating our findings. A meta-analysis by Pan et al 29 showed that their SLE patients were positive for Tg antibodies 2.9 times more frequently and for TPO antibodies 2.2 times frequently than healthy controls.…”

Section: Discussionsupporting

confidence: 89%

“…TPO, formerly known as microsomal antigen, is an enzyme that catalyzes iodination of the tyrosine residues of thyroglobulin to form monoiodotyrosine and diiodotyrosine. 5 TPO is found on the apical surface and cytoplasm of thyroid follicular cells. 4 Unlike Tg, TPO is capable of inducing antibody-dependent cell-mediated cytotoxicity and is considered to be more specific for autoimmune thyroid disease.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, iodine intake is another variable to be taken into account. 5,17 Also, in some of the rheumatic diseases mentioned, such as SpA and SSc, studies in this context are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

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BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

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“…One possible explanation for the increased risk of thyroid disease in young SLE patients might be the relatively higher disease activity in these patients [43, 44]. Nevertheless, this association between SLE activity and thyroid disease shown by previous studies is still controversial owing to limitations in study design and participant numbers, making it difficult to verify their conclusions [45, 46]. Also, as mentioned above, the use of aggressive immunosuppressive agents during the early stages of the disease can contribute to the later development of overt thyroiditis [30, 47], and the maximum inflammatory response in SLE patients would be expected after the reduction in immunosuppressive therapy.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea

et al. 2017

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We investigated the association between autoimmune thyroid disease and systemic lupus erythematosus (SLE) using nationwide insurance claims data for the entire Korean population. Claims data for the period 2009–2013 were retrieved from the National Health Insurance System database. SLE and thyroid disease were identified using the International Classification of Diseases codes and medication information. Logistic regression analyses were used to evaluate the association between SLE and thyroid disease. The study used records from 17,495 patients with SLE and 52,485 age- and sex-matched control subjects. A greater prevalence of Graves’ disease (0.94% vs. 0.46%, P < 0.001), Hashimoto’s thyroiditis (2.68% vs. 0.80%, P < 0.001), and thyroid cancer (1.81% vs. 1.30%, P < 0.001) was observed in SLE patients than in control subjects. Multivariate regression analyses demonstrated that SLE was significantly associated with an increased risk of both autoimmune thyroid disease and thyroid cancer (Graves’ disease: odds ratio [OR] 2.07, 95% confidence interval [CI] 1.70–2.53; Hashimoto’s thyroiditis: OR 3.42, 95% CI 3.00–3.91; thyroid cancer: OR 1.40, 95% CI 1.22–1.60). Age- and sex- stratified analyses revealed that the risk of autoimmune thyroid disease in SLE patients was increased for all age groups and the female group. An association between thyroid cancer and SLE was identified only in the 20- to 59-year-old age group and in the female group. Using a large population-based study, we demonstrated that patients with SLE are at a greater risk of developing thyroid disease than matched control individuals.

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“…15,16 RA hastalarında tiroid otoantikorlarının mevcudiyeti ve tiroid otoimmünitesi sık görülmüş, SLE hasta grubunda da anti-TPO %21, anti-Tg ise %10 oranında pozitif bulunmuştur. 17,18 Bu çalışmada, anti-TPO antikoru pozitif olan hastalar ve kontrol grubu olgularının hiçbirinde başka bir otoimmün hastalık, otoimmün kökenli diğer endokrinolojik patolojiler ve polikistik over sendromu görülmemiştir.…”

Section: Discussionunclassified

The Prevalence of Thyroid Autoantibodies in Multiple Sclerosis Patients

Gençer¹,

Türkoğlu²,

Çetinkaya³

et al. 2015

Turkiye Klinikleri J Neur

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Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus

Abstract: AITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke-free policies in patients with SLE.

Cited by 47 publications

References 32 publications

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea

The Prevalence of Thyroid Autoantibodies in Multiple Sclerosis Patients

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