Autoimmune thyroid disease in women with breast carcinoma

Gogas, J; Kouskos, E; Tseleni‐Balafouta, Sofia; Markopoulos, Christos; Revenas, Konstantinos; Gogas, Gerasimos; Kostakis, A.

doi:10.1053/ejso.2001.1204

Cited by 35 publications

(47 citation statements)

References 10 publications

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“…It was previously reported that the AITD prevalence is higher among breast cancer patients compared to that among healthy subjects (18)(19)(20). Surprisingly, Smyth (21) demonstrated that TPOab level is inversely correlated with tumor size and axillary nodal involvement and significantly improves the outcome of breast cancer patients.…”

Section: Introductionmentioning

confidence: 95%

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Kemal

Demirağ

Ekiz

et al. 2015

Molecular and Clinical Oncology

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Abstract. Thyroid extracts were first used to treat patients with metastatic breast cancer over a century ago. Since then, a number of studies have investigated the association between thyroid disorders and breast cancer. The presence of antibodies to thyroid peroxidase (TPOab) was recently reported to be associated with improved outcome in these patients. The aim of the present study was to evaluate the association between TPOab positivity and clinicopathological characteristics in breast cancer patients. The study included 318 newly diagnosed cases of breast cancer treated at Ondokuz Mayis University Hospital, Samsun, Turkey, between 2008 and 2012. Serum thyroid-stimulating hormone, free triiodothyronine and free thyroxine levels were measured at the time of diagnosis. Of the 318 patients, 253 were considered to be TPOab-negative (TPOab ≤34 IU/ml) and 65 TPOab-positive (TPOab >34 IU/ml). No cases with distant metastases were found in the TPOab-positive group. However, 20 (7.9%) of the 253 patients displayed distant metastases in the TPOab-negative group (P=0.01). Therefore, TPOab positivity was found to be associated with a lower incidence of metastasis in breast cancer patients.

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Section: Introductionmentioning

confidence: 95%

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Kemal

Demirağ

Ekiz

et al. 2015

Molecular and Clinical Oncology

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“…To date a relationship between specific benign thyroid diseases and BC has not been quantified with the exception of autoimmune thyroiditis (AITD), which was investigated in a metaanalysis published in 2002 [1]. This study by Sarlis et al [1] found no association between AITD and BC despite significant positive findings in an number of primary studies [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Benign thyroid disease is associated with breast cancer: a meta-analysis

Hardefeldt

Eslick

Edirimanne

2012

Breast Cancer Res Treat

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The controversial relationship between benign thyroid diseases and breast cancer (BC) has been investigated for over 50 years. Despite extensive population studies, the results as a whole have been inconsistent. The purpose of this study was to collate and analyse available data, calculating a pooled odds ratio (OR) of the risk of BC in patients diagnosed with benign thyroid diseases. Studies were obtained from a database search of MEDLINE, EMBASE, PubMed, Current Contents Connect and Google Scholar with additional cross checking of reference lists. Inclusion criteria required a confirmed diagnosis of a benign thyroid disease, reporting of an OR or data to calculate an OR (and 95% confidence interval, CI) and the use of an internal control group as the comparator. Collated data was assessed for heterogeneity and a pooled OR calculated. 28 studies were included in the meta-analysis. There was significant evidence of an increased risk of BC in patients with autoimmune thyroiditis, evident in a pooled OR 2.92 (95% CI 2.13-4.01). In addition, the results supported an increased risk associated with the presence of anti-thyroid antibodies (OR 2.02, 95% CI 1.63-2.50) and goitre (OR 2.26, 95% CI 1.39-3.69). Subgroup analysis of antibody presence revealed increased risk associated with both anti-TPO (OR 2.64, 95% CI 1.82-3.83) and anti-TG (2.71, 95% CI 1.58-4.69). Quantitative analysis of hypothyroidism and hyperthyroidism was not significant. While these results indicate an association between thyroid auto-immunity and BC, further prospective studies are required to definitively prove causality.

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“…However, the relationship between breast cancer and thyroid hormone is controversial. Even though many studies have shown that thyroid diseases are common in women with breast cancer, other reports have not confirmed this association (reviewed in 7,8). Almost every form of thyroid disease including hyperthyroidism has been identified in association with breast cancer (9-11).…”

Section: Introductionmentioning

confidence: 99%

Profile of thyroid hormones in breast cancer patients

Saraiva

Figueiredo

Padovani

et al. 2005

Braz J Med Biol Res

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Estrogen involvement in breast cancer has been established; however, the association between breast cancer and thyroid diseases is controversial. Estrogen-like effects of thyroid hormone on breast cancer cell growth in culture have been reported. The objective of the present study was to determine the profile of thyroid hormones in breast cancer patients. Serum aliquots from 26 patients with breast cancer ranging in age from 30 to 85 years and age-matched normal controls (N = 22) were analyzed for free triiodothyronine (T 3 F), free thyroxine (T 4 F), thyroid-stimulating hormone (TSH), antiperoxidase antibody (TPO), and estradiol (E 2 ). Estrogen receptor ß (ERß) was determined in tumor tissues by immunohistochemistry. Thyroid disease incidence was higher in patients than in controls (58 vs 18%, P < 0.05). Subclinical hyperthyroidism was the most frequent disorder in patients (31%); hypothyroidism (8%) and positive anti-TPO antibodies (19%) were also found. Subclinical hypothyroidism was the only dysfunction (18%) found in controls. Hyperthyroidism was associated with postmenopausal patients, as shown by significantly higher mean T 3 and T 4 values and lower TSH levels in this group of breast cancer patients than in controls. The majority of positive ERß tumors were clustered in the postmenopausal patients and all cases presenting subclinical hyperthyroidism in this subgroup concomitantly exhibited Erß-positive tumors. Subclinical hyperthyroidism was present in only one of 6 premenopausal patients. We show here that postmenopausal breast cancer patients have a significantly increased thyroid hormone/ E 2 ratio (P < 0.05), suggesting a possible tumor growth-promoting effect caused by this misbalance.

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Autoimmune thyroid disease in women with breast carcinoma

Cited by 35 publications

References 10 publications

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

Benign thyroid disease is associated with breast cancer: a meta-analysis

Profile of thyroid hormones in breast cancer patients

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