Autoimmune thyroid disease with myasthenia gravis in a 28-year-old male: a case report

Masood, Imran; Yasir, Mir; Aiman, Aiffa; Kudyar, R P

doi:10.4076/1757-1626-2-8766

Cited by 11 publications

(15 citation statements)

References 7 publications

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“…Its clinical expression is variable, ranging from a localized ocular form, to a severe, generalized attack [5,6]. It can be associated with other autoimmune conditions, such autoimmune thyroid disease, especially hyperthyroidism [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

“…The principal ocular signs of Graves' disease are exopthalmos and retraction of the superior eyelid. An associated MG should be considered if there is ptosis and/or nystagmus [6,9]. The disproportionate association between thyroid eye disease and MG seems to be related to cross-reactivity against an epitope or autoantigen that is common to the thyroid and the ocular muscles in the context of genetic predisposition [6].…”

Section: Discussionmentioning

confidence: 99%

“…An associated MG should be considered if there is ptosis and/or nystagmus [6,9]. The disproportionate association between thyroid eye disease and MG seems to be related to cross-reactivity against an epitope or autoantigen that is common to the thyroid and the ocular muscles in the context of genetic predisposition [6]. Myasthenia gravis illustrates the importance of the thymus in autoimmune diseases by its frequent association with thymus anomalies, and the important role of the thymus in its pathogenesis [4,8,10].…”

Section: Discussionmentioning

confidence: 99%

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Grave’s disease associated with myasthenia gravis: a case report

Pouye¹,

Dia²,

Ndongo³

et al. 2014

Intern Med Inside

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Purpose: The unfortunate association between myasthenia gravis and Graves' disease is not widely appreciated. It would be consistent with a genetic predisposition for autoimmune disease. The frequency of this association is variously appreciated in the literature. Case: We report a case of a 20 years old patient with a two years history of Graves' disease, who presented with a myasthenic syndrome leading to an acute respiratory failure. This was found to be reversible with prostigmine, and the diagnosis of myasthenia gravis (MG) was confirmed by EMG and positive immunology. There was a positive response to medical treatment. Discussion: The frequency of this association is variously appreciated in the literature. MG has been reported to be discovered simultaneously with, or prior to, the diagnosis of Graves' disease, but is most commonly subsequent to it. The similarity of symptoms makes diagnosis difficult. Furthermore, an excess of thyroid hormones worsens MG and the existence of MG imposes certain precautions in the management of hyperthyroidism. Conclusion: Research is called for into the surveillance and management of specific manifestations of the co-occurrence of these conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Grave’s disease associated with myasthenia gravis: a case report

Pouye¹,

Dia²,

Ndongo³

et al. 2014

Intern Med Inside

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“…MG is now regarded as one of the major autoimmune diseases. It was demonstrated that a deficiency in neuromuscu-lar transmission in the disease results from an autoimmune response to postsynaptic AChR, and that the deficiency is occasionally associated with various autoimmune disorders, such as systemic lupus erythematosus, pernicious anemia, HT, and GD [8,9] . Many studies have also shown that AITDs, such as GD and HT, are most frequently associated with MG [5,6,8] .…”

Section: Discussionmentioning

confidence: 99%

Myasthenia Gravis and Autoimunne Thyroid Disease Association

Yüksel¹

2019

Haydarpasa Numune Med J

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Introduction: Autoimmune thyroid disease (AITD) frequently accompanies myasthenia gravis (MG). The aim of the present study was to evaluate the clinical and serological features of MG associated with AITD. Methods: Thirty patients diagnosed with MG between 2012 and 2016 were followed. All patients' clinical and demographic features were analyzed, and acetylcholine receptor antibody (AChRAb) and antimicrosomal antibody were evaluated. There were 30 (21 female and nine male) patients suffering from MG. Age range was 13-78 years. Age range at disease onset was 11-75 years. Duration of disease range was 1-38 years. Results: Of the 30 patients, 17 (56.7%) were positive for AChRAb, and 7 (23%) were positive for antimicrosomal antibody. Among 17 AChRAb (+) patients, both diagnoses of generalized (14/23 (60.9%)) and ocular (3/7 (42.9%)) myasthenia were present. Of the 17 AChRAb (+) patients, 6 were also positive for antimicrosomal antibody. All seven antimicrosomal antibody (+) patients had generalized myasthenia. Discussion and Conclusion: It is really important to think coexisting MG in patients with autoimmune disorders and neuromuscular weakness. The presence of AChRAb in patients with MG is associated with a frequent risk for other autoimmune diseases.

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“…АИО может сочетаться с другой эндокринной и неэндокринной аутоиммунной патологией [6,7]. В литературе [4,5,8] имеются данные о сочетании миастении и АИО на фоне патологии щитовидной железы. Сведения о сочетании миастении и АИО немногочисленны.…”

Section: наблюдение из практикиunclassified

A case of the combination of myasthenia gravis and autoimmune eye disease with the symptoms of malignant exophthalmos

Konkova

Карнаух

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Autoimmune ophthalmopathy (AIO) is currently regarded as an independent genetically determined autoimmune disease characterized by lesions of the organs of vision and can be combined with other endocrine and non-endocrine autoimmune disorders. There are few publications about the combination and the differential diagnosis of myasthenia gravis and AIO. The authors present a clinical case of the combination of myasthenia gravis and autoimmune eye disease with the symptoms of the malignant exophthalmos. Our case report is of interest because the symptoms of AIO not only remain but became worse in pharmacological hypothyroidism that confirms the independence of this disease.

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Autoimmune thyroid disease with myasthenia gravis in a 28-year-old male: a case report

Cited by 11 publications

References 7 publications

Grave’s disease associated with myasthenia gravis: a case report

Grave’s disease associated with myasthenia gravis: a case report

Myasthenia Gravis and Autoimunne Thyroid Disease Association

A case of the combination of myasthenia gravis and autoimmune eye disease with the symptoms of malignant exophthalmos

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