Autoimmunity Ætiological Aspects of Chronic Discoid and Systemic Lupus Erythematosus, Systemic Sclerosis, and Hashimoto's Thyroiditis

Burch, P.R.J.; Rowell, N. R.

doi:10.1016/s0140-6736(63)90245-9

Cited by 83 publications

(17 citation statements)

References 15 publications

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“…The bias of case selection/attendance of psoriatics at a dermatological clinic, though, may be the same as the bias of selection/ volunteers for a control group in HL-A studies and would not affect a cor relation analysis. Burch and Rowell's [23] suggestion of two genotypes for the etiology of psoriasis is consistent with the observations of this report. The suggestion by Seignalet et al [31] that though HL-A B13 antigen frequency was ele vated in the population they tested but was not statistically significant and that HL-A B17 antigen frequency was elevated and is statistically significant, was confirmed in this analysis of HL-A antigen frequency and case rate association.…”

Section: Observations and Discussionsupporting

confidence: 92%

Psoriasis: Case Rate – HL-A Antigen Frequency Correlations

Thomas¹

1977

Dermatology

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HL-A antigen B17, associated with a high familial frequency of psoriasis, is significantly correlated (r = 0.8242) with psoriasis case rates in several countries but HL-A antigen B13 alone, associated with ‘early age onset’ cases of psoriasis, is not significantly correlated (r = 0.4299) with case rate. A sum of the B13 and B17 antigen frequencies, since either antigen has been associated to psoriasis, is correlated with case rate in the populations surveyed (r = 0.7405) and is statistically significant.

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Section: Observations and Discussionsupporting

confidence: 92%

Psoriasis: Case Rate – HL-A Antigen Frequency Correlations

Thomas¹

1977

Dermatology

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“…The age and sex in which the disease occurs is dependent upon the number of dominant inherited mutations or alleles of chromosome X, the number of somatic mutations in stem cells, the lymphoid series, the number of banned clones, the number of somatic mutations that affect chromosome X and the number of loci affected. The onset is dependent mainly on the inheritance factors related to chromosome X and autosomal genes of somatic mutations or X-loci [31].…”

Section: Slementioning

confidence: 99%

Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll-like receptors 2 and 4

Marques

Maor

Andrade

et al. 2015

Clinical and Experimental Immunology

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Summary Toll‐like receptors (TLRs) participate in the innate immune response and trigger the immune responses of the body. Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown aetiology, characterized by an excessive autoimmune response in the body affecting the connective tissues. The disease is possibly triggered by both environmental aetiological factors and pathological organic processes such as exposure to sunlight, chronic infectious processes and genetic factors. Conversely, periodontal disease is an infectious disease caused by microorganisms in the oral cavity, resulting in a chronic inflammatory process which continuously stimulates the immune response, thus causing damage to the periodontal tissues. The expression of both TLR‐2 and TLR‐4 receptors are increased in both SLE and periodontal disease. Periodontitis might trigger excessive activation of immune response occurring in SLE by maintaining a high expression of TLRs, leading in turn to the acceleration of the onset and progression of autoimmune reactions. In addition, periodontal treatment is able to reduce the expression of these receptors and therefore the symptoms of SLE. Here we discuss the possible interaction between SLE and periodontitis, and suggest further studies evaluating common features in both factors that could explored, due to morbidity and mortality of SLE and the high incidence of periodontal infections around the world.

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“…Possible genetic aspects of scleroderma have been studied by Burch and Rowell [3]. Using large population surveys, and sex and age of onset rates, these authors have theorized th at the patterns of L .E ., scleroderma, and other autoimm une diseases are quite similar.…”

Section: Discussionmentioning

confidence: 99%

Scleroderma, Immunological and Genetic Disease in Three Families

Tuffanelli¹

1969

Dermatology

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Autoimmunity Ætiological Aspects of Chronic Discoid and Systemic Lupus Erythematosus, Systemic Sclerosis, and Hashimoto's Thyroiditis

Cited by 83 publications

References 15 publications

Psoriasis: Case Rate – HL-A Antigen Frequency Correlations

Psoriasis: Case Rate – HL-A Antigen Frequency Correlations

Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll-like receptors 2 and 4

Scleroderma, Immunological and Genetic Disease in Three Families

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