2004
DOI: 10.1093/humupd/dmh014
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Autoimmunity and antigenic targets in ovarian pathology

Abstract: The involvement of autoimmune mechanisms in premature ovarian failure has been put forward by numerous investigators. In various other ovarian pathologies, such as idiopathic infertility, polycystic ovary syndrome, or endometriosis, similar mechanisms have been suggested. However, the exact role of autoimmunity in the pathophysiology of these diseases still remains controversial. The diagnosis of autoimmune ovarian disease relies on several clinical, biological and histological findings, but special interest h… Show more

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Cited by 155 publications
(119 citation statements)
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“…[43][44][45][46] It seems likely that as with SC antibodies, multiple and shared antigens among endocrine organs raises susceptibility of involvement of multiple organs, including the ovary.…”
Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning
confidence: 99%
“…[43][44][45][46] It seems likely that as with SC antibodies, multiple and shared antigens among endocrine organs raises susceptibility of involvement of multiple organs, including the ovary.…”
Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning
confidence: 99%
“…These autoantibodies have been detected in several human cancers, and significant advances have been made in the identification of their target antigens, particularly in lung cancer (28,30), colorectal cancer (36), breast cancer (29), prostate cancer (27,37), leukemia (26), non-Hodgkin lymphoma (24), hepatocellular carcinoma (25,32,34), ovarian cancer (31), pancreatic cancer (33,38), and paraneoplastic neurological syndromes (35). Although the mechanisms leading to autoantibody production in cancer patients are not clearly understood, emerging evidence indicates that most TAAs are cellular proteins whose aberrant regulation or function could be linked to malignancy (3).…”
Section: Cancer-associated Autoantibodies As Reporters Of Tumorigenesismentioning
confidence: 99%
“…Several lines of evidence indicate that autoimmunity is responsible for several ovarian disorders including POF, endometriosis, unexplained infertility, and PCOS [8,15]. Detection of AOA in these patients is suggestive of an autoimmune process in pathogenesis of the disease.…”
Section: Discussionmentioning
confidence: 97%