Autoimmunity, Diabetes, and Cystic Fibrosis

Tj, Wilkin; Stutchfield, P R; Smith, ColinS.; Heaf, D P

doi:10.1016/s0140-6736(87)92355-5

Cited by 10 publications

(2 citation statements)

References 8 publications

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“…The literature has consistently drawn conclusions based on sera from different patient groups measured in different assay systems with different detection limits and even different ligands. What little prospective data are available needs to be interpreted with (75,76) caution. Studies to assess the predictive value of markers in diabetes are almost exclusively based on the siblings and other primary relatives of diabetics.…”

Section: Clinical Issuesmentioning

confidence: 99%

Insulin Autoantibodies as Markers for Type I Diabetes

Wilkin

1990

Endocrine Reviews

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Section: Clinical Issuesmentioning

confidence: 99%

Insulin Autoantibodies as Markers for Type I Diabetes

Wilkin

1990

Endocrine Reviews

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“…Studies of genetic and immunological markers of diabetes mellitus in C F are scarce (1-7) and often preliminary (1, 3, 4, 7). I t is disputed whether diabetes mellitus in C F is related to HLA genes (1-3), islet cell antibodies (2-6) and insulin autoantibodies (5,7), as seen in insulin-dependent diabetes mellitus (IDDM) (8,9). Several restriction fragment length polyniorphisms (RFLPs) have been suggested as genetic markers for IDDM.…”

mentioning

confidence: 99%

Diabetes mellitus in cystic fibrosis: genetic and immunological markers

et al. 1993

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Family history, as well as genetic and immunological markers of diabetes mellitus, were studied in cystic fibrosis (CF) patients with and without diabetes mellitus. Positive family history of diabetes mellitus in first-degree relatives was found in only 6 of 210 (3%) CF patients, with no difference between non-diabetic and diabetic patients. The frequency distributions of the HLA types DR3, DR4 and DR3/4, which normally confer susceptibility to insulin-dependent diabetes mellitus and of HLA-DR2, which normally confers resistance to insulin-dependent diabetes mellitus, were not different in non-diabetic CF patients, diabetic CF patients and normal subjects. The genotypic frequencies of tumor necrosis factor-beta and of heat shock protein 70, located within the HLA region on chromosome 6, in CF patients with diabetes were not different from those in patients with insulin-dependent diabetes mellitus, while non-diabetic CF patients and normal subjects shared other patterns. The frequencies of the interleukin-1 beta alleles, located on chromosome 2, were not different in non-diabetic and diabetic CF patients, insulin-dependent diabetic patients and normal subjects. Islet cell cytoplasmic antibodies, measured before, at and after the diagnosis of diabetes in 33 diabetic CF patients and in 32 matched non-diabetic CF patients, were detected in only 2 of 236 (0.8%) serum samples: in a pre-diabetic patient and in a non-diabetic control patient. Birth weights were not different in diabetic and non-diabetic CF patients, arguing against the importance of the intrauterine environment as a determinant in the transmission of diabetes mellitus in CF patients.(ABSTRACT TRUNCATED AT 250 WORDS)

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Correlation of phenotypic and genetic heterogeneity in cystic fibrosis: Variability in sweat electrolyte levels contributes to heterogeneity and is increased with the XV‐2c/KM19 B haplotype

et al. 1991

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We have reinvestigated a classification of clinical heterogeneity among cystic fibrosis (CF) patients that we previously reported and investigated the possible relationship of the identified CF subgroups to haplotypes around the CF gene and to HLA-DR haplotypes. Age-corrected values for sweat electrolytes, rate of progression of lung disease as assessed by Brasfield chest x-ray scores, and severity of pancreatic insufficiency as assessed by daily supplemented enzyme dosage were obtained for 55, 59, and 59 patients, respectively. XV-2c and KM19 RFLPs were determined by hybridization to TaqI and PstI digests of human genomic DNA, respectively, and analysis of mutations by PCR amplification followed by allele-specific oligo-deoxynucleotide hybridization was performed for 29 patients. HLA-DR restriction fragment length polymorphisms (RFLPs) were determined by hybridization of cDNA beta 1 and genomic DQ alpha probes to TaqI digests of human genomic DNA. The results show that the previous subdivision on the basis of age-corrected levels of sweat electrolytes, as well as measures of severity of lung disease and pancreatic disease, is valid. In addition, the C and D haplotypes are associated with lower age-corrected sweat sodium level. No significant relationship between CF haplotypes and the other two disease variables or between HLA-DR haplotypes and any of the clinical variables was found.

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Autoimmunity, Diabetes, and Cystic Fibrosis

Cited by 10 publications

References 8 publications

Insulin Autoantibodies as Markers for Type I Diabetes

Insulin Autoantibodies as Markers for Type I Diabetes

Diabetes mellitus in cystic fibrosis: genetic and immunological markers

Correlation of phenotypic and genetic heterogeneity in cystic fibrosis: Variability in sweat electrolyte levels contributes to heterogeneity and is increased with the XV‐2c/KM19 B haplotype

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