1985
DOI: 10.1136/bjo.69.10.758
|View full text |Cite
|
Sign up to set email alerts
|

Autoimmunity in hereditary retinal degenerations. II. Clinical studies: antiretinal antibodies and fluorescein angiogram findings.

Abstract: SUMMARY Testing by indirect immunofluorescence for the detection of antiretinal antibodies and lymphocyte stimulation for cell-mediated immunity to retinal antigens was performed on blood obtained from 59 patients with retinitis pigmentosa (RP) and 29 without RP who had other types of retinal disease. The results from the patients' immunological studies were correlated in a masked fashion with six parameters of the fluorescein angiogram: disc staining, peripapillary oedema, vascular arcade oedema, macular oede… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
22
0
2

Year Published

1988
1988
2014
2014

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 60 publications
(24 citation statements)
references
References 11 publications
0
22
0
2
Order By: Relevance
“…[21][22][23][24] This barrier impairment is thought to be responsible for the release of retinal proteins into the circulation, which could be antigenic and trigger an autoimmune process contributing to the formation of CME and the presence of circulating antiretinal antibodies in RP patients. 25,26 Different modes of therapy have been tried to resolve CME in RP patients. These include laser and surgical interventions, intravitreal steroid injections, systemic corticosteroids, and both topical and oral CAI.…”
Section: Discussionmentioning
confidence: 99%
“…[21][22][23][24] This barrier impairment is thought to be responsible for the release of retinal proteins into the circulation, which could be antigenic and trigger an autoimmune process contributing to the formation of CME and the presence of circulating antiretinal antibodies in RP patients. 25,26 Different modes of therapy have been tried to resolve CME in RP patients. These include laser and surgical interventions, intravitreal steroid injections, systemic corticosteroids, and both topical and oral CAI.…”
Section: Discussionmentioning
confidence: 99%
“…33 Vascular staining and leakage on FA has been reported to occur in RP and provides an evidence for compromised bloodretinal barrier. 32,34 A faint elevation of laser flare reading was also detected in case 1 and may also be the result of the same pathophysiology.…”
Section: Discussionmentioning
confidence: 75%
“…On the other hand, it is hypothesized that CME in RP develops secondary to a RPE pumping mechanism reduction due to a dysfunction of cytoplasmic enzyme activity caused by autoantibodies. 32 Heckenlively et al 5 showed a significant association between CME and the presence of circulating anti-retinal antibodies in patients with RP, suggesting an underlying autoimmune process in the pathogenesis of RP. Thus, RP patients with secondary autoimmune complications would be expected to benefit from corticosteroid treatment.…”
Section: Discussionmentioning
confidence: 98%
“…The longitudinal relationship of CIC levels and retinal autoimmunity in posterior uveitis has been examined in three previous reports.- 5 Abrahams and Gregerson reported that there was no correlation between clinical activity and titres of antibody to S antigen in four patients with relapses-three with idiopathic disease and one with sarcoidosis.4 In a further study3 it was reported that patients with only one attack of uveitis showed a gradual decrease in antiretinal antibody titres after the acute attack, while in patients with recurrent attacks of uveitis antiretinal antibody levels were generally stable. We could not confirm this observation in patients with RV+SID, though there was a trend towards it in patients with RV alone.…”
Section: Discussionmentioning
confidence: 99%