Autoimmunity in Infectious Disease

Glynn, L. E.

doi:10.1007/978-94-011-6191-6_11

Cited by 5 publications

(10 citation statements)

References 76 publications

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“…The terminal stage of the thyroid lesions consisted of extensive infiltration with small lymphocytes, plasma cells and other mononuclear cells, complete disappearance of follicular architecture and replacement with fibrous connective tissues and fatty tissues. As far as we are aware, such severe and irreversible experimental thyroiditis due to the autoimmune mechanism have never been reported in any other experimental systems (1,6,13,15,17). The progressive and irreversible thyroid lesions produced in our system resemble those in Hashimoto's disease in man (1, 2, 5, 6).…”

Section: Discussionmentioning

confidence: 50%

“…There has been much discussion as to the possible roles of circulating antibodies and cell-mediated immunity in production of autoimmune thyroiditis (1,6,17). Many reports have suggested that the formation of thyroiditis has an intimate correlation to development of delayed hypersensitivity to thyroid antigens rather than to production of circulating antibodies (1,6,17,19,21).…”

Section: Discussionmentioning

confidence: 99%

“…Many reports have suggested that the formation of thyroiditis has an intimate correlation to development of delayed hypersensitivity to thyroid antigens rather than to production of circulating antibodies (1,6,17,19,21). Recently, however, Clagett et al (3) have suggested that circulating antibodies play an important role in production of thyroid lesions in mice injected with heterologous thyroid antigen.…”

Section: Discussionmentioning

confidence: 99%

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Microbial Adjuvant and Autoimmunity

Yokochi

Nakashima

Kato

et al. 1978

Microbiology and Immunology

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Experimental autoimmune thyroiditis could be produced in SMA, C3H/He and C57BL mice by repeated injection at intervals of 30 days of syngeneic thyroid extract mixed with the capsular polysaccharide of Klebsiella pneumoniae (CPS-K) as a powerful adjuvant. The sequence of the development of autoimmune thyroiditis was histologically followed using SMA strain of mice, in which the thyroid lesions were most marked. A single injection of the thyroid extract mixed with CPS-K induced interstitial infiltration of small lymphocytes and other mononuclear cells, and follicular architecture was partially damaged. At early times (5 to 12 days) after the secondary injection of the material, there were aggregation of polymorphonuclear neutrophilic leukocytes with formation of microabscesses in the follicles and hyaline degeneration of small vessels in the thyroid glands, suggesting that this stage of the thyroid lesions was expression of an Arthus reaction. The maximal severity of the thyroid lesions was reached at 30 days after the secondary injection. At this time, the thyroid lesions consisted of extensive infiltration of small lymphocytes, plasma cells and other mononuclear cells with complete loss of follicular architecture and mild proliferation of fibrous connective tissues. Even at 200 days after the secondary injection, there was no evidence of spontaneous regression and resolution of the thyroid lesions. Based on the histological findings, it seems likely that in our system cell-mediated immunity plays a dominant role in initiation and maintenance of thyroiditis and humoral antibodies do so in its aggravation.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Microbial Adjuvant and Autoimmunity

Yokochi

Nakashima

Kato

et al. 1978

Microbiology and Immunology

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“…A number of experimental models for various types of autoimmune diseases in man have been established in experimental animals by active immunization with autologous or homologous tissue antigens emulsified in complete Freund's adjuvant (CFA) (1,7,8,17). It seems, however, that few of them can be regarded as perfect experimental models for severe lesions in human autoimmune diseases.…”

mentioning

confidence: 99%

“…It seems, however, that few of them can be regarded as perfect experimental models for severe lesions in human autoimmune diseases. Moreover, no or only minimal pathological changes have been induced in systems using adjuvants other than CFA (1,7,8,17).…”

mentioning

confidence: 99%

Microbial Adjuvant and Autoimmunity

Nakashima

Yokochi

Kato

et al. 1977

Microbiology and Immunology

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The target organs of mice immunized with the respective syngeneic tissue extracts together with the capsular polysaccharide of Klebsiella pneumoniae (CPS-K) as a powerful adjuvant were examined for production of lesions. In 15 out of 24 mice injected three times or more with syngeneic eyeball extracts and CPS-K adjuvant at intervals approximately 30 days, severe eyeball lesions developed in which the normal structure was almost completely lost. A large part of the eyeball tissue of these mice was replaced by infiltration with cells such as lymphocytes, plasma cells and other mononuclear cells and by connective tissue. No definite eye lesions developed in mice injected with CPS-K alone, eyeball extracts alone or eyeball extracts emulsified in complete Freund's adjuvant (CFA). In all of mice injected four times with thyroid gland extracts and CPS-K at intervals of approximately 30 days, definite thyroid gland lesions were produced. In three out of five mice of this group, the thyroid lesions were so severe that the normal thyroid follicular structure was almost completely lost, and a large part of the thyroid gland was replaced by infiltration with lymphocytes, plasma cells and other mononuclear cells and in part by connective tissue. In only one out of five mice injected with thyroid gland extracts emulsified in CFA, definite but milder thyroid gland lesions developed. No definite thyroid lesions developed in the remaining four mice of this group and also in any of the mice injected with thyroid gland extracts alone or CPS-K alone. Repeated injections of lymphoid tissue extracts and CPS-K also induced pathological changes in the spleen and lymph nodes, although less marked than those in the cases of the eyes and thyroid gland. The most remarkable change was a decrease in numbers of small lymphocytes at the areas surrounding the central arterioles in the white pulp of the spleen and the post-capillary venules in the cortex of the lymph nodes. From these results it has been concluded that our system can provide new and useful models for autoimmune diseases in man.

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Evidence for autoantibody production associated with polyclonal B-cell activation by Pseudomonas aeruginosa

Garzelli¹,

Campa²,

Colizzi³

et al. 1982

Infect Immun

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Experimental infection of mice with Pseudomonas aeruginosa resulted in the polyclonal activation of B lymphocytes, as assessed by the spontaneous plaque-forming cell (PFC) response to trinitrophenyl and sheep erythrocytes. Additionally, a PFC response to bromelain-treated syngeneic erythrocytes (Br-MRBC) could be detected in infected mice, suggesting that P. aeruginosa infection might also induce activation of self-reactive B-cell clones and consequently lead to autoantibody production. Furthermore, in cultures of mouse peritoneal cells, heat-killed P. aeruginosa enhanced the development of anti-Br-MRBC PFC, even under conditions where cell division was blocked, suggesting that the in vitro P. aeruginosa-induced enhancement of anti-Br-MRBC PFC was essentially related to cell differentiation, cell division playing only a minor role. The mechanism of the in vivo and in vitro P. aeruginosa-induced activation of anti-Br-MRBC PFC are discussed.

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Autoimmunity in Infectious Disease

Cited by 5 publications

References 76 publications

Microbial Adjuvant and Autoimmunity

Microbial Adjuvant and Autoimmunity

Microbial Adjuvant and Autoimmunity

Evidence for autoantibody production associated with polyclonal B-cell activation by Pseudomonas aeruginosa

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