2021
DOI: 10.1111/imr.13043
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Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging*

Abstract: Mechanisms of autoimmunity are varied and complex, resulting from the failure of multiple layers of immune tolerance mechanisms. Failures occur in the thymus and bone marrow during lymphocyte development, in the secondary lymphoid organs during activation, and finally at the site of autoimmunity. We will discuss mechanistic insights into autoimmune processes in the periphery. The diverse nature of the cellular composition, milieu, and structure of the target tissue introduces the potential for differing mechan… Show more

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References 114 publications
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