2014
DOI: 10.1177/0961203314546021
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Autoimmunity, phospholipid-reacting antibodies and malaria immunity

Abstract: Several questions regarding the production and functioning of autoantibodies (AAb) during malaria infection remain open. Here we provide an overview of studies conducted in our laboratory that shed some light on the questions of whether antiphospholipid antibodies (aPL) and other AAb associated with autoimmune diseases (AID) can recognize Plasmodia antigens and exert anti-parasite activity; and whether anti-parasite phospholipid antibodies, produced in response to malaria, can inhibit phospholipid-induced infl… Show more

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Cited by 25 publications
(21 citation statements)
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“…Alternatively, the prevalence and accumulation of IgM did not prevent parasite persistence in CD28KO mice, which could indicate that the parasite evolved mechanisms that can subvert the immune response into a less effective type in certain circumstances. The notion of malaria-induced autoantibodies is not new; in humans, autoantibodies are produced during malaria infection [ 27 ]. A logical prediction would be that the recognition of auto-antigens by malaria-induced IgM could induce autoimmunity at some extent in chronically infected mice.…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively, the prevalence and accumulation of IgM did not prevent parasite persistence in CD28KO mice, which could indicate that the parasite evolved mechanisms that can subvert the immune response into a less effective type in certain circumstances. The notion of malaria-induced autoantibodies is not new; in humans, autoantibodies are produced during malaria infection [ 27 ]. A logical prediction would be that the recognition of auto-antigens by malaria-induced IgM could induce autoimmunity at some extent in chronically infected mice.…”
Section: Discussionmentioning
confidence: 99%
“…Also, SARS-CoV-2 has various glycoproteins (GPs): membrane GPs, spike GPs and GPs that have acetyl esterase and haemagglutination features. These GPs could be identified by the anti-GPI antibodies resulting in protection against virus infection or inducing a milder disease pattern [20].…”
Section: The Roles Of Interferons and The Neutralizing Antibodies In mentioning
confidence: 99%
“…As such, levels of inflammation, and self-foreign recognition thresholds, should be subject to tradeoffs between (i) efficacy in recognition and clearance of pathogens and (ii) degrees of damage to one’s own tissues [ 374 , 375 ]. Indeed, some level of autoimmune (autoantibody) response appears to provide protection against malaria [ 376 , 377 ].…”
Section: Infectious Disease Versus Autoimmunitymentioning
confidence: 99%