Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthy subjects.

Venables, P. J. W.; Rigby, S.; Mumford, P. A.; Markwick, J.R.; Maini, R. N.

doi:10.1136/ard.47.1.22

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Even with moderate and elevated titers of anti-GBM antibodies in one of the cases, there was no clinical or laboratory evidence of glomerular disease. It is noteworthy that even normal individuals may have increased serum levels of some autoantibodies with no manifestation of disease [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report

Monteiro¹,

Caron²,

Balda³

et al. 2006

Braz J Infect Dis

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We report on a case of a patient with HIV infection, diagnosed 18 months prior to the development of an anti-glomerular basement membrane (anti-GBM) rapidly progressive glomerulonephritis; this is probably the first report of such an association. A 30-year-old white man presented with elevation of serum creatinine (1.3 -13.5 mg/dL within one month). At admission, the urinalysis showed proteinuria of 7.2 g/L and 8,000,000 erythrocytes/mL. Renal biopsy corresponded to a crescentic diffuse proliferative glomerulonephritis mediated by anti-GBM, and serum testing for anti-GBM antibodies was positive; antinuclear antibodies (ANA) and anti-neutrophilic cytoplasmic antibodies (ANCA) were also positive. The patient underwent hemodyalisis and was treated with plasmapheresis, cyclophosphamide and prednisone. The association described here is not casual, as crescentic glomerulonephritis is not common in HIV-positive patients, anti-GBM glomerulonephritis is rare and anti-GBM antibodies are frequently observed in HIV-positive subjects when compared to the overall population. Based on the current case and on the elevated frequency of the positivity for such antibodies in this group of patients, it is advisable to be aware of the eventual association between these two conditions and to promote an active search for anti-GBM antibodies and early diagnosis of eventual urinary abnormalities in HIV-positive subjects, considering the severity of anti-GBM glomerulonephritis.

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Section: Discussionmentioning

confidence: 99%

Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report

Monteiro¹,

Caron²,

Balda³

et al. 2006

Braz J Infect Dis

View full text Add to dashboard Cite

show abstract

“…Thus our findings that IgG anti-SS-B (La) antibodies occur almost exclusively in HLA-DR3 Caucasians [16], and that normal individuals whose peripheral blood lymphocytes secrete the highest levels of anti-La antibodies under the influence of a polyclonal mitogen are HLA-DR3 [17], strongly hint that La antigens are presented to T-cells by HLA-DR3 prior to triggering of B-cells by the La antigen. Direct evidence for this hypothesis could be obtained by presenting appropriate autoantigenic peptides with defined HLA molecules to T-cell clones.…”

Section: Hla Class II Antigens: Susceptibility Factors Initiators Amentioning

confidence: 90%