Autoinflammatory disorders

Azizi, Gholamreza; Arshi, Saba; Nabavi, Mohammad; Shabestari, Mahnaz Sadeghi; Suri, Deepti; Gupta, Sudhir

doi:10.1016/b978-0-12-821028-4.00007-5

Cited by 1 publication

(1 citation statement)

References 113 publications

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“…Recurrent flares or mild to severe systemic inflammation and fever including episodic fever, urticaria-like rash, and joint involvement Increased activation of the NLRP3inflammasome and overproduction of IL-1β was associated with mutations in the NLRP3 gene Azizi et al 269 Neonatal onset multisystem inflammatory disease (NOMID) Fever, rash, and tissue damage of the nervous system, skin, and joints Mutations in the CIAS1/NLRP3 gene Alsharief et al 270 ; Huttenlocher et al 271 Deficiency of the interleukin-1receptor antagonist (DIRA)…”

Section: Urticarial Disordersmentioning

confidence: 99%

Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Zaid¹,

Sekar²,

Bonam³

et al. 2022

DDDT

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The skin is the largest organ in the human body, composed of the epidermis and the dermis. It provides protection and acts as a barrier against external menaces like allergens, chemicals, systemic toxicity, and infectious organisms. Skin disorders like cancer, dermatitis, psoriasis, wounds, skin aging, acne, and skin infection occur frequently and can impact human life. According to a growing body of evidence, several studies have reported that natural products have the potential for treating skin disorders. Building on this information, this review provides brief information about the action of the most important in vitro and in vivo research on the use of ten selected natural products in inflammatory, neoplastic, and infectious skin disorders and their mechanisms that have been reported to date. The related studies and articles were searched from several databases, including PubMed, Google, Google Scholar, and ScienceDirect. Ten natural products that have been reported widely on skin disorders were reviewed in this study, with most showing anti-inflammatory, antioxidant, anti-microbial, and anti-cancer effects as the main therapeutic actions. Overall, most of the natural products reported in this review can reduce and suppress inflammatory markers, like tumor necrosis factor-alpha (TNF-α), scavenge reactive oxygen species (ROS), induce cancer cell death through apoptosis, and prevent bacteria, fungal, and virus infections indicating their potentials. This review also highlighted the challenges and opportunities of natural products in transdermal/topical delivery systems and their safety considerations for skin disorders. Our findings indicated that natural products might be a low-cost, welltolerated, and safe treatment for skin diseases. However, a larger number of clinical trials are required to validate these findings. Natural products in combination with modern drugs, as well as the development of novel delivery mechanisms, represent a very promising area for future drug discovery of these natural leads against skin disorders.

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Section: Urticarial Disordersmentioning

confidence: 99%