Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury

Adipose‐derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model

“…ASCs can be obtained in a non‐invasive manner, can undergo significant expansion within weeks, and, processes are currently being developed to make ASCs increasingly accessible at the point‐of‐care . Recent rodent studies have shown that ASCs promote muscle mass retention after PNI when administered into the denervated muscle and show cellular regeneration in both muscle ischemia and muscle atrophy‐inducing burn models . Additionally, the inflammatory response in muscle repair is essential to its healing process .…”

“…12 Recent rodent studies have shown that ASCs promote muscle mass retention after PNI when administered into the denervated muscle 13,14 and show cellular regeneration in both muscle ischemia 15 and muscle atrophy-inducing burn models. 16 Additionally, the inflammatory response in muscle repair is essential to its healing process. 17 ASCs have been implicated as having an innate mechanism to mediate local inflammatory responses.…”

Mesenchymal stem cells from human umbilical cord ameliorate testicular dysfunction in a male rat hypogonadism model

“…To answer this question, we used HUMSCs instead of rat MSCs, and we marked HUMSCs with CM-Dil, which is a good cell tracer that is not only unaffected by cell proliferation and differentiation 23 but is also able to keep cells stained for longer than 4 weeks in vivo . 24 We also did not find any obvious immunologic rejection after the transplantation. As an immunologically privileged organ, the testis contains few immunocytes, and HUMSCs do not express the major histocompatibility complex (MHC) class II (HLA-DR) antigens.…”

Holistic Approach to Axonal Regeneration in Cases of Spinal Cord Injury

“…Neuronal cell death is the primary pathogenetic mechanism in SCI; however, recent advances in stem cell therapy have increased the potential for such therapeutic techniques to benefit the replacement and regeneration of cells, the alleviation of degeneration symptoms, and the recovery of nerve function in the spinal cord [4][5][6][7]. Nonetheless, further development of stem cell therapy techniques has been hampered by logistical and ethical considerations [8][9][10], and the hostile microenvironment at the epicenter of the injury inhibits the survival, integration, and/or endogenous repair of transplanted cells [11,12]. These challenges have led researchers to adopt a holistic approach to the treatment of SCI -one that focus on altering the injury microenvironment in order to promote the survival and differentiation of transplanted cells [13][14][15].…”