Autologous blood pleurodesis: A good choice in patients with persistent air leak

Çobanoğlu, Ufuk; Melek, Mehmet; Edirne, Yeşim

doi:10.4103/1817-1737.56011

Cited by 39 publications

(39 citation statements)

References 21 publications

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“…To our knowledge, this study is among the largest (with 68 patients) to examine the experience with blood pleurodesis in patients with prolonged air leakage after lung resection. The success rate of the procedure was 67.6%, similar to previous reports [15,[20][21][22]. The main limitations of this study include its retrospective design and the lack of a control group for comparison.…”

Section: Discussionsupporting

confidence: 83%

Blood pleurodesis for air leak after pulmonary resection

Akçıl¹,

Hatipoğlu²,

Cansever³

et al. 2019

Curr Thorac Surg

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Background: Blood pleurodesis procedures were generally performed for patients with prolonged air leakage due to pneumothorax. This study investigates the use of blood pleurodesis in patients with prolonged air leak after lung resection and the variables affecting its success. Materials and Methods: A total of 493 patients who underwent anatomical lung resection for nonsmall cell lung cancer between January 2012 and December 2016 were evaluated retrospectively. 68 (13.7%) patients who underwent blood pleurodesis were included the study group. The success rate of the procedure was evaluated according to age, gender, side and type of the surgery, histopathology, and the expansion of the lungs and air leakage. Results: The success rate was not related to age, sex, side of the operation, histopathology, and type of the resection, while it was found to be statistically significant for the air leakage score (p < 0.001). The procedure was successful in 46 (67.6%) patients and failed in 22 (32.3%) patients. Conclusions: The blood pleurodesis is a safe, effective and low cost method for treatment of postoperative air leakage in patients with anatomical lung resection for primary lung carcinoma.

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Section: Discussionsupporting

confidence: 83%

Blood pleurodesis for air leak after pulmonary resection

Akçıl¹,

Hatipoğlu²,

Cansever³

et al. 2019

Curr Thorac Surg

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“…Indeed, the rate of patients who required invasive procedures was higher in the present study (34%) than that reported in previous studies (3.8-20.4%) (9)(10)(11). Pneumothorax patients treated with a longer duration of chest tube drainage are reported to have a high risk for developing respiratory infection, empyema formation and deep venous thrombosis (7,8). We believe that our strategy, namely conversion to invasive procedures in pneumothorax patients with prolonged air leaks based on thoracographic findings, is therefore justified, considering the risks associated with longterm chest tube drainage.…”

Section: Discussioncontrasting

confidence: 50%

“…However, conversion to invasive procedures in pneumothorax patients with prolonged air leakage requires skilled clinical judgment. Pneumothorax may resolve spontaneously in a large proportion of patients, who do not require invasive procedures, while other pneumothorax patients have a high risk of respiratory infection, empyema formation and deep venous thrombosis due to the inappropriate use of VATS (7,8).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Pneumothorax with Persistent Air Leakage and Invasive Procedures

2013

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Objective Prolonged air leaks in patients with spontaneous pneumothorax are not infrequent. The aim of this study was to assess the duration of air leaks and define the clinical variables associated with the therapeutic success of chest tube drainage for spontaneous pneumothorax. Methods A total of 441 patients with spontaneous pneumothorax treated with chest tube drainage between 2008 and 2012 were retrospectively evaluated. The clinical differences between the patients successfully treated with drainage and those who required more invasive procedures were analyzed. Results Invasive procedures, such as video-assisted thoracic surgery (n=121), fibrin glue administration through a chest tube (n=8) and pleurodesis with OK-432 (n=21), were performed in 34% (150/441) of the patients. The treatment rate of chest drainage alone was higher in the patients with initial pneumothorax (72%; 124/170) than in those with recurrent pneumothorax (62%; 167/271) (p=0.015). In addition, this rate was higher in the patients with moderate lung collapse (70%; 167/237) than in those with severe lung collapse (61%; 124/204) (p=0.032). Conclusion Patients with recurrent pneumothorax or severe lung collapse associated with prolonged air leakage are more likely to receive invasive procedures.

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“…Bu hasta grubunda tüp torakostomi uygulamasını takiben otolog kan, talk veya tetrasiklin gibi değişik ajanlar kullanılarak yapılan plörodez yöntemlerinde değişik başarı oranları elde edilmiştir. [15] Ayrıca göğüs cerrahisinde ameliyat sonrası hava kaçaklarını azaltmak için BioGlue ® (CryoLife Europa Ltd, Hampshire, United Kingdom), Peri-strips ® (Synovis Life Technologies Inc, St Paul MN, USA) ve Tachosil ® (Nycomed Pharma AS, Linz Austria) gibi doğal ve sentetik doku yapıştırıcıları kullanılarak farklı oranlarda başarılar elde edilmiştir. [3,16] Buna karşın Kawamura ve ark.…”

Section: Discussionunclassified

Evaluation of the effects of ankaferd blood stopper on rabbits with paranchyme damage: an experımental study

Metin¹

2013

Turk Gogus Kalp Dama

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Çalışmada pulmoner parenkim hasarı yapılan tavşanlarda, geleneksel Türk hekimliğinde hemostatik ajan olarak kullanılmış bir bitkisel ekstrakt olan Ankaferd Blood Stopper'in (ABS) kanama kontrolü, yara iyileşmesi, hava kaçağı ve plevral yapışıklık üzerindeki etkinliği değerlendirildi. Ça lış ma pla nı: Ortalama ağırlıkları 2500 gr olan 16 adet Yeni Zelanda Albino türü erkek ve dişi tavşan kullanıldı. Tavşanlar çalışma ve kontrol grubu olarak iki gruba ayrıldı. Her iki grupta birer tavşan anestezi sırasında öldü. Tüm tavşanların sol alt loblarına eşit büyüklükte kama rezeksiyon yapıldı. Çalışma grubunda rezeksiyon alanına 5 puf (~1 cc) ABS sprey uygulanır iken, kontrol grubuna ek bir işlem yapılmadı. İki gruba da uygulanan tüp torakostomi, ameliyat sonrası altı saat drenaj ve hava kaçağı takibi sonrası sonlandırıldı. Ameliyat sonrası sekizinci gün tavşanlar yüksek doz anestezi ile sakrifiye edildi. Hemitorakstaki plevral enflamasyon ve fibrozis makroskopik ve mikroskopik olarak incelendi. Doku malondialdehit (MDA) ve hidroksiprolin (HPR) düzeylerinin biyokimyasal ölçümleri yapıldı. Bul gu lar: Ameliyat sonrası hava kaçağı ve drenaj miktarı açısından iki grup arasındaki fark istatistiksel olarak anlamlı idi (kanama miktarı p<0.05, hava kaçağı p<0.001). Çalışma grubunda makroskopik ve mikroskopik fibrozis yüksek düzeyde gözlendi (p<0.0001). Doku MDA düzeyleri bakımından iki grup karşılaştırıldığında, ABS uygulanan grupta MDA düzeyinin düştüğü görülmek ile birlikte, fark istatistiksel açıdan anlamlı değil idi. So nuç: Ankaferd Blood Stopper toksik etkiye yol açmadan ameliyat sonrası kanamaları ve uzamış hava kaçaklarını azaltmakta ve plevral fibrozis düzeyini artırarak plörodezde etkin rol oynamaktadır. Anah tar söz cük ler: Ankaferd; plörodez; ameliyat sonrası komplikasyon. Background: In this study, we aimed to evaluate the effects of Ankaferd Blood Stopper (ABS), a herbal extract used as a hemostatic agent in traditional Turkish medicine, on hemostasis, wound healing, air leakage and the efficiency over pleural adhesions in rabbits with pulmonary parenchymal damage. Methods: Sixteen New Zelland Albino type male and female rabbits with a mean weight of 2500 g were used. The rabbits were divided into two groups as study group and control group. One rabbit in each group died during anesthesia. We performed wedge resections in equal size to the left lower lobes of all rabbits. No additional procedure was performed on the control group, while the study group received 5 puffs (~1 cc) of ABS to the resection area. Tube thoracostomy, which was performed in both groups, was terminated postoperatively at the sixth hours after drainage and air leakage follow-up. The rabbits were sacrificed with high dose anesthetic at the postoperative eight-day. Pleural inflammation and fibrosis in the hemithorax were examined macroscopically and microscopically. Biochemical measurements of tissue malondialdehyde (MDA) and hydroxyprolin (HPR) levels were done. Results: There was a statistically significant difference in postoperative air lea...

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Autologous blood pleurodesis: A good choice in patients with persistent air leak

Cited by 39 publications

References 21 publications

Blood pleurodesis for air leak after pulmonary resection

Blood pleurodesis for air leak after pulmonary resection

Spontaneous Pneumothorax with Persistent Air Leakage and Invasive Procedures

Evaluation of the effects of ankaferd blood stopper on rabbits with paranchyme damage: an experımental study

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