Autologous Blood Products in Rotator Cuff Repair

Mei-Dan, Omer; Carmont, Michael R.

doi:10.1159/000328904

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…This classification system is based on the absolute number of platelets (P), the method of platelet activation (A), and the presence/absence of white cells (W). Recently, PRP has been utilized for numerous musculoskeletal indications such as rotator cuff repair 3,4 , patellar tendinopathy 5 , knee osteoarthritis 6 , lateral epicondylitis 7 , osteochondral lesions of the talus 8 , and many other orthopaedic conditions. PRP induces musculoskeletal healing through a number of effects.…”

Section: Introductionmentioning

confidence: 99%

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

Kraeutler

Garabekyan

Mei-Dan³

2019

Muscle Ligaments and Tendons J

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Background: In recent years, platelet-rich plasma (PRP) has gained popularity within the orthopaedic community as a treatment modality to enhance tissue healing. Purpose: This review aims to concisely present the current indications for PRP injections in the treatment of hip and pelvic pathologies and to describe some novel applications for PRP which have not yet been reported in the literature. Methods: We reviewed the literature on the non-operative and operative indications for PRP in the treatment of hip and pelvic pathologies. Conclusions: With regard to hip and pelvic pathologies, PRP injections are used most commonly as a non-operative intervention, and have been described in the literature to treat osteoarthritis of the hip joint as well as tendinopathy of the hamstrings, adductor longus, and gluteus medius. In contrast, most of the surgical applications of PRP for the hip are novel, with few reported studies in the literature. Because of the increasing awareness of PRP's beneficial effects on musculoskeletal healing and thus the growing number of indications for its use, this review also describes some novel applications for PRP, including osteitis pubis, post-microfracture of the hip, tears of the rectus femoris, and avulsion of the sartorius muscle. Level of evidence: V.

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Section: Introductionmentioning

confidence: 99%

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

Kraeutler

Garabekyan

Mei-Dan³

2019

Muscle Ligaments and Tendons J

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“…Lately PRP has become very popular among the orthopaedic community as a minimally invasive way of enhancing tissue healing in different conditions including rotator cuff repair [ 14 , 15 ], patellar tendinopathy [ 16 , 17 ], knee osteoarthritis [ 18 ], lateral epicondylitis [ 19 ], osteochondral lesions of the talus [ 20 ] and other orthopaedic conditions. It has been postulated that PRP promotes soft tissue healing by delivering a higher than normal concentration of platelets and therefore increased concentration of platelet derived growth factors to the diseased area [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The use of platelet-rich plasma in the treatment of greater trochanteric pain syndrome: a systematic literature review

Ali

Oderuth

Atchia

et al. 2018

Journal of Hip Preservation Surgery

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This review aims to determine whether platelet-rich plasma (PRP) has any role in improving clinical outcomes in patients with symptomatic greater trochanteric pain syndrome (GTPS). A search of NICE healthcare database advanced search (HDAS) via Athens (PubMed, MEDLINE, CINAHL, EMBASE and AMED databases) was conducted from their year of inception to April 2018 with the keywords: ‘greater trochanteric pain syndrome’ or ‘GTPS’ or ‘gluteus medius’ or ‘trochanteric bursitis’ and ‘platelet rich plasma’ (PRP). A quality assessment was performed using the JADAD score for RCTs and MINORS for non-RCT studies. Five full-text articles were included for analysis consisting of three RCTs and two case series. We also identified four additional studies from published conference abstracts (one RCT and three case series). The mean age in 209 patients was 58.4 years (range 48–76.2 years). The majority of patients were females and the minimum duration of symptoms was three months. Diagnosis was made using ultrasound or MRI. Included studies used a variety of outcome measures. Improvement was observed during the first 3 months after injection. Significant improvement was also noted when patients were followed up till 12 months post treatment. PRP seems a viable alternative injectable option for GTPS refractory to conservative measures. The current literature has revealed that PRP is relatively safe and can be effective. Considering the limitations in these studies, more large-sample and high-quality randomized clinical trials are required in the future to provide further evidence of the efficacy for PRP as a treatment in GTPS.Systematic Review RegistrationPROSPERO CRD42017080662Level of EvidenceLevel I, systematic review of Level I studies.

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“…[ 7 8 ] Several studies have reported the healing potential of autologous platelet-rich plasma (PRP) on tendons and especially on those of the rotator cuff. [ 9 10 11 12 13 ] They have been shown to decrease postoperative pain and to improve early clinical results. [ 14 ] These autologous conditioned plasma (ACP) are rich in growth factors, contained in the a-granules of the platelets.…”

Section: Introductionmentioning

confidence: 99%

Arthroscopic double row cuff repair with suture-bridging and autologous conditioned plasma injection: Functional and structural results

Werthel

Pelissier

Massin

et al. 2014

Int J Shoulder Surg

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Purpose:The double row cuff repair with suture bridging is commonly used for arthroscopic rotator cuff repair (RCR). Despite its biomechanical qualities, the rate of iterative tears with this technique is important. The aim of our study was to evaluate the effect of autologous conditioned plasma (ACP) on functional results and on the rate of iterative tears after RCR by suture bridging.Materials and Methods:A consecutive series of 65 patients who underwent arthroscopic double-row suture bridge (Speed-Bridge, Arthrex) primary cuff repair of symptomatic full-thickness supraspinatus tear (retraction <3 in the Patte classification) were evaluated. Mean patient age was 60 (+/-8). The supraspinatus was repaired by knot-less bridging (SwiveLock, Arthrex) with suture tape material. 2 homogenous groups were created (A: 33 patients, B: 32 patients). In group A, all patients received, besides the cuff repair, an intra-tendinous ACP injection. Constant scores and Simple Shoulder Tests (SST) were measured pre-operatively and after a minimum follow-up period of 12 months post-operatively. Structural integrity of the repairs was evaluated by MRI according to the Sugaya classification. Sugaya >4 were considered as iterative tears.Results:Mean follow-up was 19 months (+/−42) in the 2 groups. The mean quantity of ACP injected was 6ml. (+/−1.5) and no specific complication of the injection was found. Mean preoperative Constant-Murley scores were 41,2 (±7,7) and 38 (±11)in group B. Mean normalized Constant-Murley score increased from 41 points (±7) pre-operatively to 70 points (±8) post-operatively in group A and from 38 points (±11) to 73 points (±11) in group B. There were no significative differences between the two groups (P > 0.05). In group A, 31 repairs were Sugaya 1-3 (94%), vs. 30 in group B (93%), and 1 was type 4 in group A (5%) vs. 2 in group B (8%).Conclusion:In both groups, RCR with suture bridging gave successful functional outcomes, with a low rate of iterative tear. In this preliminary study, the adjuvant effect of ACP injections could not be showed on both functional and structural results. Longer follow-up is needed to evaluate potential differences.

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Autologous Blood Products in Rotator Cuff Repair

Cited by 6 publications

References 49 publications

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

The use of platelet-rich plasma in the treatment of greater trochanteric pain syndrome: a systematic literature review

Arthroscopic double row cuff repair with suture-bridging and autologous conditioned plasma injection: Functional and structural results

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